ID   MDTH_PHOLL              Reviewed;         401 AA.
AC   Q7N568;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Multidrug resistance protein MdtH {ECO:0000255|HAMAP-Rule:MF_01529};
GN   Name=mdtH {ECO:0000255|HAMAP-Rule:MF_01529}; OrderedLocusNames=plu2089;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01529}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01529}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtH (TC 2.A.1.2.21) subfamily. {ECO:0000255|HAMAP-Rule:MF_01529}.
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DR   EMBL; BX571866; CAE14382.1; -; Genomic_DNA.
DR   RefSeq; WP_011146344.1; NC_005126.1.
DR   AlphaFoldDB; Q7N568; -.
DR   SMR; Q7N568; -.
DR   STRING; 243265.plu2089; -.
DR   EnsemblBacteria; CAE14382; CAE14382; plu2089.
DR   GeneID; 24166548; -.
DR   KEGG; plu:plu2089; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_001265_60_2_6; -.
DR   OMA; TVCVWTL; -.
DR   OrthoDB; 1452500at2; -.
DR   BioCyc; PLUM243265:PLU_RS10440-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01529; MFS_MdtH; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR022855; Multidrug-R_MdtH.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..401
FT                   /note="Multidrug resistance protein MdtH"
FT                   /id="PRO_0000173346"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        78..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        99..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
SQ   SEQUENCE   401 AA;  44383 MW;  046A2631B285ED7C CRC64;
     MSLVSQARSL GKYFLLFDNL LVVLGFFVVF PLISIHFVEQ LGWAALVVGF ALGLRQFVQQ
     GLGIFGGAIA DRFGAKPMIV TGMLLRALGF AFIALATEPW ILWLACILSA LGGTLFDPPR
     TALVIKLTRP HERGRFFSLL LMQDSAGAVI GALIGSWLLQ YDFQFVCWTG AGVFVLAAIW
     NALFLPAYRI STTRTPIWEG MERVIKDRRF FTYVLTLTGY FMLSVQVMLM FPIIVNEIAG
     TPAAVKWMYA IEATLSLTLL YPIARWSEKR FRLEQRLMAG LFLMSLSMFP VGLIGEINTL
     FGLICLFYLG TVTAEPARET LSASLADPRA RGSYMGFSRL GLALGGALGY TGGGWLYDTG
     HALNIPQLPW FLLGIIGLIT LYALHRQFNQ RKIESAMLSG N