ID   MDTH_PROMH              Reviewed;         400 AA.
AC   B4ETN1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Multidrug resistance protein MdtH {ECO:0000255|HAMAP-Rule:MF_01529};
GN   Name=mdtH {ECO:0000255|HAMAP-Rule:MF_01529}; OrderedLocusNames=PMI1099;
OS   Proteus mirabilis (strain HI4320).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI4320;
RX   PubMed=18375554; DOI=10.1128/jb.01981-07;
RA   Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA   Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA   Parkhill J., Mobley H.L.T.;
RT   "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT   both adherence and motility.";
RL   J. Bacteriol. 190:4027-4037(2008).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01529}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01529}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtH (TC 2.A.1.2.21) subfamily. {ECO:0000255|HAMAP-Rule:MF_01529}.
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DR   EMBL; AM942759; CAR42374.1; -; Genomic_DNA.
DR   RefSeq; WP_012367855.1; NC_010554.1.
DR   AlphaFoldDB; B4ETN1; -.
DR   SMR; B4ETN1; -.
DR   STRING; 529507.PMI1099; -.
DR   EnsemblBacteria; CAR42374; CAR42374; PMI1099.
DR   GeneID; 6801060; -.
DR   KEGG; pmr:PMI1099; -.
DR   PATRIC; fig|529507.6.peg.1063; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_001265_60_2_6; -.
DR   OMA; TVCVWTL; -.
DR   Proteomes; UP000008319; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01529; MFS_MdtH; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR022855; Multidrug-R_MdtH.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..400
FT                   /note="Multidrug resistance protein MdtH"
FT                   /id="PRO_1000200803"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        99..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
SQ   SEQUENCE   400 AA;  44390 MW;  48D37EDBD85AC275 CRC64;
     MALVTQARTL GKYFLLLDNM LVVLGFFVVF PLISIRFVEQ LGWAGVIVGF ALGLRQLVQQ
     GLGIFGGAIA DRFGAKPMII TGMLLRALGF ALMALADKPW ILWLSCILSA LGGTLFDPPR
     TALVIKLTRP YERGRFYSLL LMQDSAGAVI GALIGSWLLL YDFHLVCWVG AGIFVLAAIF
     NAWLLPAYRI STTRTPIKEG LKRVILDKRF VQYVLTLTGY FVLSVQVMLM FPIVVNEIAG
     TPSAVKWMYA IEALLSLTLL YPIARWSEKH FRLEQRLMAG LFLMSISMFP VGITHSLHAI
     FLIITLFYLG TITAEPARET LSASLADPRA RGSYMGFSRL GLAFGGAIGY TGGGWMYDIG
     KQLELPELPW FLLGSIGFIT LYALHRQFNR KKIETAMLTP