ID   MDTI_CROS8              Reviewed;         109 AA.
AC   A7MEJ5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Spermidine export protein MdtI;
GN   Name=mdtI; OrderedLocusNames=ESA_01730;
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894;
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA   Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA   McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT   hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with MdtJ. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01597}.
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DR   EMBL; CP000783; ABU76984.1; -; Genomic_DNA.
DR   RefSeq; WP_007775321.1; NC_009778.1.
DR   AlphaFoldDB; A7MEJ5; -.
DR   SMR; A7MEJ5; -.
DR   EnsemblBacteria; ABU76984; ABU76984; ESA_01730.
DR   GeneID; 45715521; -.
DR   GeneID; 56730552; -.
DR   KEGG; esa:ESA_01730; -.
DR   HOGENOM; CLU_133067_0_4_6; -.
DR   OMA; VAAGWIM; -.
DR   OrthoDB; 1921902at2; -.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015606; F:spermidine transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   InterPro; IPR023737; Spermidine_export_MdtI.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   PANTHER; PTHR30561:SF6; PTHR30561:SF6; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..109
FT                   /note="Spermidine export protein MdtI"
FT                   /id="PRO_0000331135"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   109 AA;  11595 MW;  F90C7D5704D5F664 CRC64;
     MSQVELQHIL WLLLAIGLEI IANIWLKFSD GFRRPVYGVA SLAAVLAAFS ALGQAVEGID
     LAVAYALWGG FGIAATVAAG WIMFGQRLNR KGWAGLGLLL VGMVIIKLA