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MDTI_ECOL5
ID   MDTI_ECOL5              Reviewed;         109 AA.
AC   Q0THM9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Spermidine export protein MdtI {ECO:0000255|HAMAP-Rule:MF_01597};
GN   Name=mdtI {ECO:0000255|HAMAP-Rule:MF_01597}; OrderedLocusNames=ECP_1543;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=536 / UPEC;
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000255|HAMAP-
CC       Rule:MF_01597}.
CC   -!- SUBUNIT: Forms a complex with MdtJ. {ECO:0000255|HAMAP-Rule:MF_01597}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01597}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01597}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01597}.
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DR   EMBL; CP000247; ABG69550.1; -; Genomic_DNA.
DR   RefSeq; WP_000046660.1; NC_008253.1.
DR   AlphaFoldDB; Q0THM9; -.
DR   SMR; Q0THM9; -.
DR   STRING; 362663.ECP_1543; -.
DR   EnsemblBacteria; ABG69550; ABG69550; ECP_1543.
DR   KEGG; ecp:ECP_1543; -.
DR   HOGENOM; CLU_133067_0_4_6; -.
DR   OMA; VAAGWIM; -.
DR   Proteomes; UP000009182; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015606; F:spermidine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   HAMAP; MF_01597; MdtI; 1.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   InterPro; IPR023737; Spermidine_export_MdtI.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   PANTHER; PTHR30561:SF6; PTHR30561:SF6; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..109
FT                   /note="Spermidine export protein MdtI"
FT                   /id="PRO_0000331140"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
SQ   SEQUENCE   109 AA;  11667 MW;  A7AF618D5CA2BB97 CRC64;
     MAQFEWVHAA WLALAIVLEI VANVFLKFSD GFRCKIFGLL SLAAVLAAFS ALSQAVKGID
     LSVAYALWGG FGIAATLAAG WILFGQRLNR KGWIGLVLLL AGMIMVKLA
 
 
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