ID   MDTI_ENT38              Reviewed;         109 AA.
AC   A4WA58;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Spermidine export protein MdtI {ECO:0000255|HAMAP-Rule:MF_01597};
GN   Name=mdtI {ECO:0000255|HAMAP-Rule:MF_01597}; OrderedLocusNames=Ent638_1912;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000255|HAMAP-
CC       Rule:MF_01597}.
CC   -!- SUBUNIT: Forms a complex with MdtJ. {ECO:0000255|HAMAP-Rule:MF_01597}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01597}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01597}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01597}.
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DR   EMBL; CP000653; ABP60588.1; -; Genomic_DNA.
DR   RefSeq; WP_012017303.1; NC_009436.1.
DR   AlphaFoldDB; A4WA58; -.
DR   SMR; A4WA58; -.
DR   STRING; 399742.Ent638_1912; -.
DR   EnsemblBacteria; ABP60588; ABP60588; Ent638_1912.
DR   KEGG; ent:Ent638_1912; -.
DR   eggNOG; COG2076; Bacteria.
DR   HOGENOM; CLU_133067_0_4_6; -.
DR   OMA; VAAGWIM; -.
DR   OrthoDB; 1921902at2; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015606; F:spermidine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   HAMAP; MF_01597; MdtI; 1.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   InterPro; IPR023737; Spermidine_export_MdtI.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   PANTHER; PTHR30561:SF6; PTHR30561:SF6; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..109
FT                   /note="Spermidine export protein MdtI"
FT                   /id="PRO_0000331136"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
SQ   SEQUENCE   109 AA;  11884 MW;  B59B4E5B620DD116 CRC64;
     MQQFEWIHAA WLAFAIVLEI IANVFLKFSD GFRRKWFGLL SIAAVLGAFS ALSQAVKGID
     LSVAYALWGG FGIAATLAAG WVLFGQRLNR KGWIGLVLLL AGMVMIKLA