ID   MDTI_SALTY              Reviewed;         109 AA.
AC   Q7CQK0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Spermidine export protein MdtI {ECO:0000255|HAMAP-Rule:MF_01597};
GN   Name=mdtI {ECO:0000255|HAMAP-Rule:MF_01597}; OrderedLocusNames=STM1483;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000255|HAMAP-
CC       Rule:MF_01597}.
CC   -!- SUBUNIT: Forms a complex with MdtJ. {ECO:0000255|HAMAP-Rule:MF_01597}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01597}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01597}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01597}.
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DR   EMBL; AE006468; AAL20402.1; -; Genomic_DNA.
DR   RefSeq; NP_460443.1; NC_003197.2.
DR   RefSeq; WP_001183821.1; NC_003197.2.
DR   AlphaFoldDB; Q7CQK0; -.
DR   SMR; Q7CQK0; -.
DR   STRING; 99287.STM1483; -.
DR   PaxDb; Q7CQK0; -.
DR   DNASU; 1253001; -.
DR   EnsemblBacteria; AAL20402; AAL20402; STM1483.
DR   GeneID; 1253001; -.
DR   KEGG; stm:STM1483; -.
DR   PATRIC; fig|99287.12.peg.1567; -.
DR   HOGENOM; CLU_133067_0_4_6; -.
DR   OMA; VAAGWIM; -.
DR   PhylomeDB; Q7CQK0; -.
DR   BioCyc; SENT99287:STM1483-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015199; F:amino-acid betaine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0015220; F:choline transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015606; F:spermidine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015871; P:choline transport; IBA:GO_Central.
DR   GO; GO:0031460; P:glycine betaine transport; IBA:GO_Central.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   GO; GO:1903711; P:spermidine transmembrane transport; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   HAMAP; MF_01597; MdtI; 1.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   InterPro; IPR023737; Spermidine_export_MdtI.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   PANTHER; PTHR30561:SF6; PTHR30561:SF6; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..109
FT                   /note="Spermidine export protein MdtI"
FT                   /id="PRO_0000331149"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
SQ   SEQUENCE   109 AA;  11686 MW;  694140463A4D4484 CRC64;
     MQQFEWIHGA WLGLAIMLEI AANVLLKFSD GFRRKCYGIL SLAAVLAAFS ALSQAVKGID
     LSVAYALWGG FGIAATLAAG WVLFGQRLNP KGWVGVILLL AGMVMIKFA