MDTI_YERPE
ID MDTI_YERPE Reviewed; 109 AA.
AC Q0WF87; Q74U39; Q8D0F4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Spermidine export protein MdtI {ECO:0000255|HAMAP-Rule:MF_01597};
GN Name=mdtI {ECO:0000255|HAMAP-Rule:MF_01597};
GN OrderedLocusNames=YPO2069, y2241, YP_1912;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000255|HAMAP-
CC Rule:MF_01597}.
CC -!- SUBUNIT: Forms a complex with MdtJ. {ECO:0000255|HAMAP-Rule:MF_01597}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01597}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01597}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01597}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM85801.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS62130.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAL20704.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL20704.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE009952; AAM85801.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS62130.1; ALT_INIT; Genomic_DNA.
DR PIR; AE0252; AE0252.
DR RefSeq; WP_002211187.1; NZ_WUCM01000062.1.
DR RefSeq; YP_002347051.1; NC_003143.1.
DR AlphaFoldDB; Q0WF87; -.
DR SMR; Q0WF87; -.
DR IntAct; Q0WF87; 2.
DR STRING; 214092.YPO2069; -.
DR PaxDb; Q0WF87; -.
DR DNASU; 1147188; -.
DR EnsemblBacteria; AAM85801; AAM85801; y2241.
DR EnsemblBacteria; AAS62130; AAS62130; YP_1912.
DR GeneID; 57976592; -.
DR KEGG; ype:YPO2069; -.
DR KEGG; ypk:y2241; -.
DR KEGG; ypm:YP_1912; -.
DR PATRIC; fig|214092.21.peg.2458; -.
DR eggNOG; COG2076; Bacteria.
DR HOGENOM; CLU_133067_0_4_6; -.
DR OMA; VAAGWIM; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015199; F:amino-acid betaine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0015220; F:choline transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015871; P:choline transport; IBA:GO_Central.
DR GO; GO:0031460; P:glycine betaine transport; IBA:GO_Central.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR GO; GO:1903711; P:spermidine transmembrane transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR HAMAP; MF_01597; MdtI; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR InterPro; IPR023737; Spermidine_export_MdtI.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR PANTHER; PTHR30561:SF6; PTHR30561:SF6; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..109
FT /note="Spermidine export protein MdtI"
FT /id="PRO_0000331157"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
SQ SEQUENCE 109 AA; 11917 MW; 230186AC1F9022F6 CRC64;
MQQLEFYPIA FLILAVMLEI VANILLKMSD GFRRKWLGIL SLLSVLGAFS ALAQAVKGIE
LSVAYALWGG FGIAATVAAG WILFNQRLNY KGWIGLILLL AGMVMIKLS
