MDTI_YERPN
ID MDTI_YERPN Reviewed; 109 AA.
AC Q1CJF4; C4GSH5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Spermidine export protein MdtI {ECO:0000255|HAMAP-Rule:MF_01597};
GN Name=mdtI {ECO:0000255|HAMAP-Rule:MF_01597}; OrderedLocusNames=YPN_1546;
GN ORFNames=YP516_1717;
OS Yersinia pestis bv. Antiqua (strain Nepal516).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=377628;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nepal516;
RX PubMed=16740952; DOI=10.1128/jb.00124-06;
RA Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA Worsham P., Chu M.C., Andersen G.L.;
RT "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT evidence of gene reduction in an emerging pathogen.";
RL J. Bacteriol. 188:4453-4463(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nepal516;
RA Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R.,
RA Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.;
RT "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000255|HAMAP-
CC Rule:MF_01597}.
CC -!- SUBUNIT: Forms a complex with MdtJ. {ECO:0000255|HAMAP-Rule:MF_01597}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01597}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01597}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01597}.
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DR EMBL; CP000305; ABG17876.1; -; Genomic_DNA.
DR EMBL; ACNQ01000009; EEO76985.1; -; Genomic_DNA.
DR RefSeq; WP_002211187.1; NZ_ACNQ01000009.1.
DR AlphaFoldDB; Q1CJF4; -.
DR SMR; Q1CJF4; -.
DR EnsemblBacteria; ABG17876; ABG17876; YPN_1546.
DR GeneID; 57976592; -.
DR KEGG; ypn:YPN_1546; -.
DR HOGENOM; CLU_133067_0_4_6; -.
DR OMA; VAAGWIM; -.
DR Proteomes; UP000008936; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR HAMAP; MF_01597; MdtI; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR InterPro; IPR023737; Spermidine_export_MdtI.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR PANTHER; PTHR30561:SF6; PTHR30561:SF6; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..109
FT /note="Spermidine export protein MdtI"
FT /id="PRO_0000331159"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01597"
SQ SEQUENCE 109 AA; 11917 MW; 230186AC1F9022F6 CRC64;
MQQLEFYPIA FLILAVMLEI VANILLKMSD GFRRKWLGIL SLLSVLGAFS ALAQAVKGIE
LSVAYALWGG FGIAATVAAG WILFNQRLNY KGWIGLILLL AGMVMIKLS
