MDTJ_PHOLL
ID MDTJ_PHOLL Reviewed; 138 AA.
AC Q7N537;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Spermidine export protein MdtJ {ECO:0000255|HAMAP-Rule:MF_01598};
GN Name=mdtJ {ECO:0000255|HAMAP-Rule:MF_01598}; OrderedLocusNames=plu2123;
OS Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS TT01).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=243265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15139 / CIP 105565 / TT01;
RX PubMed=14528314; DOI=10.1038/nbt886;
RA Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA Glaser P., Boemare N., Danchin A., Kunst F.;
RT "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT luminescens.";
RL Nat. Biotechnol. 21:1307-1313(2003).
CC -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000255|HAMAP-
CC Rule:MF_01598}.
CC -!- SUBUNIT: Forms a complex with MdtI. {ECO:0000255|HAMAP-Rule:MF_01598}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01598}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01598}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01598}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX571866; CAE14416.1; -; Genomic_DNA.
DR RefSeq; WP_011146377.1; NC_005126.1.
DR AlphaFoldDB; Q7N537; -.
DR SMR; Q7N537; -.
DR STRING; 243265.plu2123; -.
DR PRIDE; Q7N537; -.
DR EnsemblBacteria; CAE14416; CAE14416; plu2123.
DR GeneID; 24166515; -.
DR KEGG; plu:plu2123; -.
DR eggNOG; COG2076; Bacteria.
DR HOGENOM; CLU_133067_0_0_6; -.
DR OMA; MRSWIYL; -.
DR OrthoDB; 1921902at2; -.
DR BioCyc; PLUM243265:PLU_RS10605-MON; -.
DR Proteomes; UP000002514; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR HAMAP; MF_01598; MdtJ; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR InterPro; IPR023740; Spermidine_export_MdtJ.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR PANTHER; PTHR30561:SF2; PTHR30561:SF2; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..138
FT /note="Spermidine export protein MdtJ"
FT /id="PRO_0000331172"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
SQ SEQUENCE 138 AA; 14725 MW; 8AC4C9A5133E8C98 CRC64;
MIYWLFLAMA IITEVIGTLS MKHASVSGGV VGMAVMYIMI ATSYILLAMA VKKVALGVAY
ALWEGVGILF ITVFSVMWFD ESLSLMKVGG LALLITGIML IKSGTRKAAV KKSAEVVKQM
ANKAVSVATT KSSKIKEA