MDTJ_SALAR
ID MDTJ_SALAR Reviewed; 120 AA.
AC A9MRT9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Spermidine export protein MdtJ {ECO:0000255|HAMAP-Rule:MF_01598};
GN Name=mdtJ {ECO:0000255|HAMAP-Rule:MF_01598}; OrderedLocusNames=SARI_01496;
OS Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=41514;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980;
RG The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA Johnson M., Thiruvilangam P., Wilson R.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000255|HAMAP-
CC Rule:MF_01598}.
CC -!- SUBUNIT: Forms a complex with MdtI. {ECO:0000255|HAMAP-Rule:MF_01598}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01598}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01598}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01598}.
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DR EMBL; CP000880; ABX21392.1; -; Genomic_DNA.
DR RefSeq; WP_000500282.1; NC_010067.1.
DR AlphaFoldDB; A9MRT9; -.
DR SMR; A9MRT9; -.
DR STRING; 41514.SARI_01496; -.
DR EnsemblBacteria; ABX21392; ABX21392; SARI_01496.
DR KEGG; ses:SARI_01496; -.
DR HOGENOM; CLU_133067_0_0_6; -.
DR OMA; MRSWIYL; -.
DR OrthoDB; 1921902at2; -.
DR Proteomes; UP000002084; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR HAMAP; MF_01598; MdtJ; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR InterPro; IPR023740; Spermidine_export_MdtJ.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR PANTHER; PTHR30561:SF2; PTHR30561:SF2; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..120
FT /note="Spermidine export protein MdtJ"
FT /id="PRO_0000331173"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
SQ SEQUENCE 120 AA; 13013 MW; 802AD5AA291B04E7 CRC64;
MFYWILLALA IVAEITGTLS MKWASVGNGN AGYILMLVMI TLSYIFLSFA VKKIALGVAY
ALWEGIGILF ITVFSVLLFD EVLSTMKIVG LLTLIVGIVL IKSGTRKPGK PVKEATRATI