MDTJ_YERPE
ID MDTJ_YERPE Reviewed; 147 AA.
AC Q7CIC6; Q74U40;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Spermidine export protein MdtJ {ECO:0000255|HAMAP-Rule:MF_01598};
GN Name=mdtJ {ECO:0000255|HAMAP-Rule:MF_01598};
GN OrderedLocusNames=YPO2068, y2242, YP_1911;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000255|HAMAP-
CC Rule:MF_01598}.
CC -!- SUBUNIT: Forms a complex with MdtI. {ECO:0000255|HAMAP-Rule:MF_01598}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01598}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01598}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01598}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM85802.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS62129.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAL20703.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL590842; CAL20703.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE009952; AAM85802.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS62129.1; ALT_INIT; Genomic_DNA.
DR PIR; AD0252; AD0252.
DR RefSeq; WP_002211188.1; NZ_WHLN01000023.1.
DR RefSeq; YP_002347050.1; NC_003143.1.
DR AlphaFoldDB; Q7CIC6; -.
DR SMR; Q7CIC6; -.
DR STRING; 214092.YPO2068; -.
DR PaxDb; Q7CIC6; -.
DR DNASU; 1147189; -.
DR EnsemblBacteria; AAM85802; AAM85802; y2242.
DR EnsemblBacteria; AAS62129; AAS62129; YP_1911.
DR GeneID; 57976593; -.
DR KEGG; ype:YPO2068; -.
DR KEGG; ypk:y2242; -.
DR KEGG; ypm:YP_1911; -.
DR PATRIC; fig|214092.21.peg.2457; -.
DR eggNOG; COG2076; Bacteria.
DR HOGENOM; CLU_133067_0_0_6; -.
DR OMA; MRSWIYL; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015199; F:amino-acid betaine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0015220; F:choline transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015871; P:choline transport; IBA:GO_Central.
DR GO; GO:0031460; P:glycine betaine transport; IBA:GO_Central.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR GO; GO:1903711; P:spermidine transmembrane transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR HAMAP; MF_01598; MdtJ; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR InterPro; IPR023740; Spermidine_export_MdtJ.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR PANTHER; PTHR30561:SF2; PTHR30561:SF2; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..147
FT /note="Spermidine export protein MdtJ"
FT /id="PRO_0000331186"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01598"
FT REGION 105..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 147 AA; 15852 MW; CABDD4B0FE25D24F CRC64;
MIYWIFLGLA IIAEIIGTLS MKYASVSGEM TGHIVMYFMI TGSYVMLSLA VKKVALGVAY
ALWEGIGILI ITIFSVMWFG ETLSPLKIAG LVTLIGGILL VKSGTRKPKQ PNCHRGNRPP
SVQELKTQTT GHHKGVAVES GEHHAAA
