ID   MDTK_CROS8              Reviewed;         457 AA.
AC   A7MFC3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Multidrug resistance protein MdtK {ECO:0000255|HAMAP-Rule:MF_00400};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000255|HAMAP-Rule:MF_00400};
GN   Name=mdtK {ECO:0000255|HAMAP-Rule:MF_00400}; OrderedLocusNames=ESA_02027;
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894;
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA   Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA   McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT   hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- FUNCTION: Multidrug efflux pump that functions probably as a Na(+)/drug
CC       antiporter. {ECO:0000255|HAMAP-Rule:MF_00400}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00400}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00400}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MdtK subfamily. {ECO:0000255|HAMAP-Rule:MF_00400}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000783; ABU77280.1; -; Genomic_DNA.
DR   RefSeq; WP_012124929.1; NC_009778.1.
DR   AlphaFoldDB; A7MFC3; -.
DR   SMR; A7MFC3; -.
DR   PRIDE; A7MFC3; -.
DR   EnsemblBacteria; ABU77280; ABU77280; ESA_02027.
DR   KEGG; esa:ESA_02027; -.
DR   PATRIC; fig|290339.8.peg.1810; -.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; EFWILLK; -.
DR   OrthoDB; 1415498at2; -.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006855; P:xenobiotic transmembrane transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00400; MdtK; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR022913; Multidrug-R_MdtK.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..457
FT                   /note="Multidrug resistance protein MdtK"
FT                   /id="PRO_1000049613"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
SQ   SEQUENCE   457 AA;  49941 MW;  09AA5D7782CEFD1A CRC64;
     MQKYFVEARQ LLALAIPVIF AQIAQTSMGV VDTVMAGGYS ATDMAAVAIG TSIWLPAILF
     GHGLLLALTP VIAQLNGSGR RDRIAHQVQQ GFVLAGLVSV LIMLVLWNAG YIIHAMHNID
     PVLANKAVNY LRALLWGAPG YLFFQVMRNQ CEGLAKTTPG MAMGFIGLLV NIPVNYIFIY
     GHFGMPELGG VGCGVATASV YWVMFFCMRF WVKRAGSMRD IRPEPASRRF DWPVIRRLAQ
     IGMPVALALF FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS MSAAVTIRVG
     FRLGQGSTLE AQTSARTGII VGICLAVLTA LFTVVFREPI ALLYNDNPEV VTLASHLMLL
     AAIYQISDSI QVIGSGVLRG YKDTRSIFFI TFIAYWVLGL PSGYILGLTD WVVEPMGPAG
     FWFGFILGLT SAAIMMMWRM RYLQRQPSET ILARAAR