ID   MDTK_PECAS              Reviewed;         457 AA.
AC   Q6D5W6;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Multidrug resistance protein MdtK {ECO:0000255|HAMAP-Rule:MF_00400};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000255|HAMAP-Rule:MF_00400};
GN   Name=mdtK {ECO:0000255|HAMAP-Rule:MF_00400}; Synonyms=norM;
GN   OrderedLocusNames=ECA1922;
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT   subsp. atroseptica and characterization of virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC   -!- FUNCTION: Multidrug efflux pump that functions probably as a Na(+)/drug
CC       antiporter. {ECO:0000255|HAMAP-Rule:MF_00400}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00400}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00400}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MdtK subfamily. {ECO:0000255|HAMAP-Rule:MF_00400}.
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DR   EMBL; BX950851; CAG74825.1; -; Genomic_DNA.
DR   RefSeq; WP_011093490.1; NC_004547.2.
DR   AlphaFoldDB; Q6D5W6; -.
DR   SMR; Q6D5W6; -.
DR   STRING; 218491.ECA1922; -.
DR   EnsemblBacteria; CAG74825; CAG74825; ECA1922.
DR   KEGG; eca:ECA1922; -.
DR   PATRIC; fig|218491.5.peg.1954; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; EFWILLK; -.
DR   OrthoDB; 1415498at2; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006855; P:xenobiotic transmembrane transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00400; MdtK; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR022913; Multidrug-R_MdtK.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..457
FT                   /note="Multidrug resistance protein MdtK"
FT                   /id="PRO_0000164185"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
SQ   SEQUENCE   457 AA;  49456 MW;  FC9A61CC42FE28C1 CRC64;
     MQQYLTEARK LSALAVPVII AQVSQTSMGV VDTIMAGAYS ATDMAAVAVG TSIWLPAILF
     GHGLLLALTP VVAQLNGSGR RDRISHQVRQ SFFLAAIISV LTMLVLYQGE YAINLMSNDS
     PELAAKAIGY LHALLWGVPG YLFYQVLRCQ CEGLSKTYPG MMIGFIGLLI NIPINYIFIH
     GKFGMPELGG VGCGVATASV YWIMMLLMML YTQRASWLRD IRLHRPAFRP DFTVLKRLFG
     LGLPIALALL FEVTLFAVVA LLVLPLGVVN VAGHQIALNF SSLMFVLPLS VGVATTIRVG
     HRLGEGSVDN ARIAAHTGIM AGVALACCTA IFTTLLREPI ALLYNQDPLV VAMASQLMLL
     AAVYQISDAV QVIGTGVLRG YKDTRSIFYI TFVAYWVLGL PSGYLLALTD VIVPRMGPAG
     FWCGFIIGLT AAAVMMVTRI RFLQRQPAAR ILARAAR