ID   MDTK_SALG2              Reviewed;         457 AA.
AC   B5RAN4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Multidrug resistance protein MdtK {ECO:0000255|HAMAP-Rule:MF_00400};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000255|HAMAP-Rule:MF_00400};
GN   Name=mdtK {ECO:0000255|HAMAP-Rule:MF_00400}; OrderedLocusNames=SG1693;
OS   Salmonella gallinarum (strain 287/91 / NCTC 13346).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=550538;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=287/91 / NCTC 13346;
RX   PubMed=18583645; DOI=10.1101/gr.077404.108;
RA   Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA   Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA   Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA   Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA   Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K., Moule S.,
RA   Mungall K., Saunders M., Whitehead S., Chabalgoity J.A., Maskell D.,
RA   Humphreys T., Roberts M., Barrow P.A., Dougan G., Parkhill J.;
RT   "Comparative genome analysis of Salmonella enteritidis PT4 and Salmonella
RT   gallinarum 287/91 provides insights into evolutionary and host adaptation
RT   pathways.";
RL   Genome Res. 18:1624-1637(2008).
CC   -!- FUNCTION: Multidrug efflux pump that functions probably as a Na(+)/drug
CC       antiporter. {ECO:0000255|HAMAP-Rule:MF_00400}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00400}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00400}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MdtK subfamily. {ECO:0000255|HAMAP-Rule:MF_00400}.
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DR   EMBL; AM933173; CAR37552.1; -; Genomic_DNA.
DR   RefSeq; WP_001175071.1; NC_011274.1.
DR   AlphaFoldDB; B5RAN4; -.
DR   SMR; B5RAN4; -.
DR   EnsemblBacteria; CAR37552; CAR37552; SG1693.
DR   KEGG; seg:SG1693; -.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000008321; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006855; P:xenobiotic transmembrane transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00400; MdtK; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR022913; Multidrug-R_MdtK.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..457
FT                   /note="Multidrug resistance protein MdtK"
FT                   /id="PRO_1000191103"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
SQ   SEQUENCE   457 AA;  49440 MW;  3CCA04F3ABE73E44 CRC64;
     MQKYTSEARQ LLALAIPVIL AQVAQTAMGF VDTVMAGGYS ATDMAAVAIG TSIWLPAILF
     GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV LVMIVLWNAG YIIRSMHNID
     PALADKAVGY LRALLWGAPG YLFFQVARNQ CEGLAKTKPG MVMGFLGLLV NIPVNYIFIY
     GHFGMPELGG IGCGVATAAV YWVMFIAMLS YIKHARSMRD IRNEKGFGKP DSIVMKRLIQ
     LGLPIALALF FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG
     YRLGQGSTLD AQTAARTGLG VGICMAVVTA IFTVTLRKHI ALLYNDNPEV VALAAQLMLL
     AAVYQISDSI QVIGSGILRG YKDTRSIFFI TFTAYWVLGL PSGYILALTD LVVDRMGPAG
     FWMGFIIGLT SAAVLMMLRM RYLQRQPSAI ILQRAAR