MDTK_YERPG
ID MDTK_YERPG Reviewed; 457 AA.
AC A9QZC0;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Multidrug resistance protein MdtK {ECO:0000255|HAMAP-Rule:MF_00400};
DE AltName: Full=Multidrug-efflux transporter {ECO:0000255|HAMAP-Rule:MF_00400};
GN Name=mdtK {ECO:0000255|HAMAP-Rule:MF_00400};
GN OrderedLocusNames=YpAngola_A2579;
OS Yersinia pestis bv. Antiqua (strain Angola).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=349746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Angola;
RX PubMed=20061468; DOI=10.1128/jb.01518-09;
RA Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA Achtman M., Lindler L.E., Ravel J.;
RT "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT new insights into the evolution and pangenome of the plague bacterium.";
RL J. Bacteriol. 192:1685-1699(2010).
CC -!- FUNCTION: Multidrug efflux pump that functions probably as a Na(+)/drug
CC antiporter. {ECO:0000255|HAMAP-Rule:MF_00400}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00400}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00400}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. MdtK subfamily. {ECO:0000255|HAMAP-Rule:MF_00400}.
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DR EMBL; CP000901; ABX86849.1; -; Genomic_DNA.
DR RefSeq; WP_002210937.1; NZ_CP009935.1.
DR AlphaFoldDB; A9QZC0; -.
DR SMR; A9QZC0; -.
DR GeneID; 66841264; -.
DR KEGG; ypg:YpAngola_A2579; -.
DR PATRIC; fig|349746.12.peg.3605; -.
DR OMA; EFWILLK; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006855; P:xenobiotic transmembrane transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00400; MdtK; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR022913; Multidrug-R_MdtK.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..457
FT /note="Multidrug resistance protein MdtK"
FT /id="PRO_1000191109"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 283..301
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
SQ SEQUENCE 457 AA; 49401 MW; AF81A08BC3B47987 CRC64;
MQKYIVEARS LLALAIPVVI AQLSQTAMGV VDTIMAGSVS ATDMAAVAVG TSIWLPAILF
GHGLLLALTP TVAQLNGSGR RSQIAHQVRQ GFWLALCVSV LIMLVLYNSD HVIKQMDNID
PVLAQKAVGF LHAIMWGVPG YLFFQVLRNQ CEGLSKTKPG MVIGFVGLLV NIPINYIFIY
GKFGAPALGG VGCGVATASV YWVMFLMMRW YVTRARSQQD IKLEKGFAAP DWQVMKRLSG
LGLPVALALF FEVTLFAVVA LLVSPLGIVA VAGHQIALNF SSLMFMLPMS LSVAATIRVG
FRLGQGAVEQ AQVAAYTSMA VGLLLASVTA VFTIVFREHI ALLYNKTPEV VTMASHLMLL
AALYQLSDAV QVIGSGVLRG YKDTRSIFFI TFTAYWLLGL PSGYLLGLTD YILPAMGPAG
FWIGFIIGLT AAAILMVLRI RWLQKQPTAF ILQRAAH
