ID   MDTL_KLEP7              Reviewed;         392 AA.
AC   A6TG19;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Multidrug resistance protein MdtL {ECO:0000255|HAMAP-Rule:MF_01530};
GN   Name=mdtL {ECO:0000255|HAMAP-Rule:MF_01530};
GN   OrderedLocusNames=KPN78578_40790; ORFNames=KPN_04120;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01530}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01530}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtL (TC 2.A.1.2.22) subfamily. {ECO:0000255|HAMAP-Rule:MF_01530}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000647; ABR79503.1; -; Genomic_DNA.
DR   RefSeq; WP_015959187.1; NC_009648.1.
DR   AlphaFoldDB; A6TG19; -.
DR   SMR; A6TG19; -.
DR   STRING; 272620.KPN_04120; -.
DR   EnsemblBacteria; ABR79503; ABR79503; KPN_04120.
DR   KEGG; kpn:KPN_04120; -.
DR   HOGENOM; CLU_001265_47_1_6; -.
DR   OMA; AGSCYVV; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01530; MFS_MdtL; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023697; Multidrug-R_MdtL.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..392
FT                   /note="Multidrug resistance protein MdtL"
FT                   /id="PRO_1000068687"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
SQ   SEQUENCE   392 AA;  41826 MW;  B033DFDF39C7AB26 CRC64;
     MTRFLLCSFA LVLLYPSGID MYLVGLPRIA QDLGASEAQL HIAFSVYLAG MASAMLFAGR
     IADRSGRKPV AIVGAAIFVI ASLICAQVHT SSHFLIGRFI QGIAAGSCYV VAFAILRDTL
     DDRRRAKVLS LLNGITCIIP VLAPVLGHLI MLKYPWQSLF YTMTGMGVMV AVLSVFILRE
     TRPTAPPQAA LPQHDAGESL LNRFFLSRLL ITTLSVTVIL TYVNVSPVLM MEEMGFDRGT
     YSMAMALMAM ISMAVSFSTP FVLSLFNPRT LMLTSQVLFL AAGVTLSLAT RQAVTLIGLG
     MICAGFSVGF GVAMSQALGP FTLRAGVASS VLGIAQVCGS SLWIWLAAII GLSAMNMLIG
     ILIACSIVSL VLLLVVTPPR VAQYDEEAAV ES