ID   MDTL_SALAR              Reviewed;         395 AA.
AC   A9MJT5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Multidrug resistance protein MdtL {ECO:0000255|HAMAP-Rule:MF_01530};
GN   Name=mdtL {ECO:0000255|HAMAP-Rule:MF_01530}; OrderedLocusNames=SARI_03802;
OS   Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=41514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980;
RG   The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01530}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01530}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtL (TC 2.A.1.2.22) subfamily. {ECO:0000255|HAMAP-Rule:MF_01530}.
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DR   EMBL; CP000880; ABX23596.1; -; Genomic_DNA.
DR   RefSeq; WP_000819630.1; NC_010067.1.
DR   AlphaFoldDB; A9MJT5; -.
DR   SMR; A9MJT5; -.
DR   STRING; 41514.SARI_03802; -.
DR   EnsemblBacteria; ABX23596; ABX23596; SARI_03802.
DR   KEGG; ses:SARI_03802; -.
DR   HOGENOM; CLU_001265_47_1_6; -.
DR   OMA; AGSCYVV; -.
DR   OrthoDB; 1452500at2; -.
DR   Proteomes; UP000002084; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01530; MFS_MdtL; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023697; Multidrug-R_MdtL.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..395
FT                   /note="Multidrug resistance protein MdtL"
FT                   /id="PRO_1000087592"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        328..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        355..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
SQ   SEQUENCE   395 AA;  42290 MW;  6A67D78618F21094 CRC64;
     MKRFLLCSFT LILLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG MATAMLFAGK
     IADRSGRKPV AIVGAIVFMM ASLLCSQATE GSLFLSGRFL QGVGAGSCYV VAFAILRDTL
     DERRRAKVLS LLNGITCIVP VLAPVLGHLI MLRFPWQSLF YTMSAMGIIV CLLSLFILRE
     TRPARLAPRD LSRSSHAAES LINRFFLSRL AITTLSVSVI LTFVNASPVL LMEVMEFSRG
     DYAITMALTA GVSMVVSFST PFALGLFKPR TLMLVSQGLF LTAGVTLSLA HTNTVTLFGL
     MLICAGFPVG FGVAMSQALG PFSLRAGVAS STLGIAQVCG SSLWIWLAAI LGISALNMLI
     GILIGCSIVS MLLILSVAPN RSISEHEEIH NQSRP