ID   MDTL_SALEP              Reviewed;         395 AA.
AC   B5QUQ6;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Multidrug resistance protein MdtL {ECO:0000255|HAMAP-Rule:MF_01530};
GN   Name=mdtL {ECO:0000255|HAMAP-Rule:MF_01530}; OrderedLocusNames=SEN3661;
OS   Salmonella enteritidis PT4 (strain P125109).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=550537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P125109;
RX   PubMed=18583645; DOI=10.1101/gr.077404.108;
RA   Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA   Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA   Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA   Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA   Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K., Moule S.,
RA   Mungall K., Saunders M., Whitehead S., Chabalgoity J.A., Maskell D.,
RA   Humphreys T., Roberts M., Barrow P.A., Dougan G., Parkhill J.;
RT   "Comparative genome analysis of Salmonella enteritidis PT4 and Salmonella
RT   gallinarum 287/91 provides insights into evolutionary and host adaptation
RT   pathways.";
RL   Genome Res. 18:1624-1637(2008).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01530}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01530}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtL (TC 2.A.1.2.22) subfamily. {ECO:0000255|HAMAP-Rule:MF_01530}.
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DR   EMBL; AM933172; CAR35237.1; -; Genomic_DNA.
DR   RefSeq; WP_000819602.1; NC_011294.1.
DR   AlphaFoldDB; B5QUQ6; -.
DR   SMR; B5QUQ6; -.
DR   KEGG; set:SEN3661; -.
DR   HOGENOM; CLU_001265_47_1_6; -.
DR   OMA; AGSCYVV; -.
DR   Proteomes; UP000000613; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01530; MFS_MdtL; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023697; Multidrug-R_MdtL.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..395
FT                   /note="Multidrug resistance protein MdtL"
FT                   /id="PRO_1000200828"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        328..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        355..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
SQ   SEQUENCE   395 AA;  42041 MW;  9F01620985AC378D CRC64;
     MKRFLLCSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG MATAMLFAGK
     IADQSGRKPV AIVGAIVFMM ASLLCSRASE GSLFLSGRFL QGIGAGGCYV VAFAILRDTL
     DEHRRAKVLS LLNGITCIVP VLAPVVGHLI MLRFPWQSLF YTMSAMGIIV GLLSLFILRE
     TRPVRLAPRD LSRSSPAAES LINRFFVSRL AITTLSVSVI LTFVNASPVL LMEVMGFSRG
     DYAITMALTA GVSMVVSFST PFALGLFKPR TLMLVSQGLF LTAGVTLSLA HTNTVTLFGL
     TLICAGFSVG FGVAMSQALG PFSLRAGVAS STLGIAQVCG SSLWIWLAAI LGISAMNMLI
     GILIGCSIVS ILLIFSVTPN RSVAEHEEIP YQSRP