MDTL_SALPB
ID MDTL_SALPB Reviewed; 395 AA.
AC A9MX86;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Multidrug resistance protein MdtL {ECO:0000255|HAMAP-Rule:MF_01530};
GN Name=mdtL {ECO:0000255|HAMAP-Rule:MF_01530}; OrderedLocusNames=SPAB_04786;
OS Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=1016998;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1250 / SPB7;
RG The Salmonella enterica serovar Paratyphi B Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA Fulton R., Cordes M., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA Johnson M., Thiruvilangam P., Wilson R.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01530}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01530}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC MdtL (TC 2.A.1.2.22) subfamily. {ECO:0000255|HAMAP-Rule:MF_01530}.
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DR EMBL; CP000886; ABX70097.1; -; Genomic_DNA.
DR RefSeq; WP_000819615.1; NC_010102.1.
DR AlphaFoldDB; A9MX86; -.
DR SMR; A9MX86; -.
DR KEGG; spq:SPAB_04786; -.
DR PATRIC; fig|1016998.12.peg.4502; -.
DR HOGENOM; CLU_001265_47_1_6; -.
DR OMA; AGSCYVV; -.
DR BioCyc; SENT1016998:SPAB_RS19425-MON; -.
DR Proteomes; UP000008556; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01530; MFS_MdtL; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023697; Multidrug-R_MdtL.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..395
FT /note="Multidrug resistance protein MdtL"
FT /id="PRO_1000087593"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 328..350
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT TRANSMEM 355..377
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
SQ SEQUENCE 395 AA; 41985 MW; 9FA55C1A97A9C347 CRC64;
MKRFLLCSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG MATAMLFAGK
IADQSGRKPV AIVGALVFMM ASLLCSRASE GSLFLSGRFL QGVGAGGCYV VAFAILRDTL
DEHRRAKVLS LLNGITCIVP VLAPVVGHLI MLRFPWQSLF YTMSAMGIIV GLLSLFILRE
TRPARLAPRD LSRSSPAAES LVNRFFVSRL AITTLSVSVI LTFVNASPVL LMEVMGFSRG
DYAITMALTA GVSMVVSFST PFALGLFKPR TLMLVSQGLF LTAGVTLSLA HTNTVTLFGL
TLICAGFSVG FGVAMSQALG PFSLRAGVAS STLGIAQVCG SSLWIWLAAI LGISAMNMLI
GILIGCSIVS ILLIFSVTPN RSVAEHEEIP YQSRP