ID   MDTL_SALPK              Reviewed;         395 AA.
AC   B5BIM0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Multidrug resistance protein MdtL {ECO:0000255|HAMAP-Rule:MF_01530};
GN   Name=mdtL {ECO:0000255|HAMAP-Rule:MF_01530}; OrderedLocusNames=SSPA3443;
OS   Salmonella paratyphi A (strain AKU_12601).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=554290;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AKU_12601;
RX   PubMed=19159446; DOI=10.1186/1471-2164-10-36;
RA   Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A.,
RA   Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N.,
RA   Mungall K., Dougan G., Parkhill J.;
RT   "Pseudogene accumulation in the evolutionary histories of Salmonella
RT   enterica serovars Paratyphi A and Typhi.";
RL   BMC Genomics 10:36-36(2009).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01530}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01530}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtL (TC 2.A.1.2.22) subfamily. {ECO:0000255|HAMAP-Rule:MF_01530}.
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DR   EMBL; FM200053; CAR61718.1; -; Genomic_DNA.
DR   RefSeq; WP_000819607.1; NC_011147.1.
DR   AlphaFoldDB; B5BIM0; -.
DR   SMR; B5BIM0; -.
DR   KEGG; sek:SSPA3443; -.
DR   HOGENOM; CLU_001265_47_1_6; -.
DR   OMA; AGSCYVV; -.
DR   Proteomes; UP000001869; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01530; MFS_MdtL; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023697; Multidrug-R_MdtL.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..395
FT                   /note="Multidrug resistance protein MdtL"
FT                   /id="PRO_1000200831"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01530"
SQ   SEQUENCE   395 AA;  42037 MW;  8AFD25E23DAD2546 CRC64;
     MKRFLLCSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG MATAMLFAGK
     IADQSGRKPV AIVGAIVFMM ASLLCSRASE GSLFLSGRFL QGVGAGGCYV VAFAILRDTL
     DEHRRAKVLS LLNGITCIVP VLAPVMGHLI MLRFPWQSLF YTMSTMGIIV GLLSLFILRE
     TRPARLAPRD LSRSSPAAES LVNRFFVSRL AITTLSVSVI LTFVNASPVL LMEVMGFSRG
     DYAITMALTA GVSMVVSFST PFALGLFKPR TLMLVSQGLF LTAGVTLSLA HTNTVTLFGL
     MLICAGFSVG FGVAMSQALG PFSLRAGVAS STLGIAQVCG SSLWIWLAAI LGISAMNMLI
     GILIGCSIVS ILLIFSVAPN RSVAEHEEIP YQSRS