MDTL_SALTY
ID MDTL_SALTY Reviewed; 395 AA.
AC Q8ZKY1; Q9FDH5;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Multidrug resistance protein MdtL;
GN Name=mdtL; OrderedLocusNames=STM3847;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-209.
RC STRAIN=DT104 / 96-5227;
RX PubMed=11544236; DOI=10.1128/jb.183.19.5725-5732.2001;
RA Boyd D., Peters G.A., Cloeckaert A., Boumedine K.S., Chaslus-Dancla E.,
RA Imberechts H., Mulvey M.R.;
RT "Complete nucleotide sequence of a 43-kilobase genomic island associated
RT with the multidrug resistance region of Salmonella enterica serovar
RT Typhimurium DT104 and its identification in phage type DT120 and serovar
RT Agona.";
RL J. Bacteriol. 183:5725-5732(2001).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC MdtL (TC 2.A.1.2.22) subfamily. {ECO:0000305}.
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DR EMBL; AE006468; AAL22705.1; -; Genomic_DNA.
DR EMBL; AF261825; AAG03011.1; -; Genomic_DNA.
DR RefSeq; NP_462746.1; NC_003197.2.
DR RefSeq; WP_000819619.1; NC_003197.2.
DR AlphaFoldDB; Q8ZKY1; -.
DR SMR; Q8ZKY1; -.
DR STRING; 99287.STM3847; -.
DR PaxDb; Q8ZKY1; -.
DR EnsemblBacteria; AAL22705; AAL22705; STM3847.
DR GeneID; 1255374; -.
DR KEGG; stm:STM3847; -.
DR PATRIC; fig|99287.12.peg.4076; -.
DR HOGENOM; CLU_001265_47_1_6; -.
DR OMA; AGSCYVV; -.
DR PhylomeDB; Q8ZKY1; -.
DR BioCyc; SENT99287:STM3847-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IBA:GO_Central.
DR HAMAP; MF_01530; MFS_MdtL; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023697; Multidrug-R_MdtL.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..395
FT /note="Multidrug resistance protein MdtL"
FT /id="PRO_0000173360"
FT TOPO_DOM 1..3
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..41
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..92
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..157
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..246
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..294
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..354
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 395 AA; 42027 MW; 7EE41CFF058E629F CRC64;
MKRFLLCSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG MATAMLFAGK
IADQSGRKPV AIVGALVFMM ASLLCSRASE GSLFLSGRFL QGVGAGGCYV VAFAILRDTL
DEHRRAKVLS LLNGITCIVP VLAPVVGHLI MLRFPWQSLF YTMSAMGIIV GLLSLFILRE
TRPVRLAPRD LSRSSPAAES LINRFFVSRL AITTLSVSVI LTFVNASPVL LMEVMGFSRG
DYAITMALTA GVSMVVSFST PFALGLFKPR TLMLVSQGLF LTAGVTLSLA HTNTVTLFGL
TLICAGFSVG FGVAMSQALG PFSLRAGVAS STLGIAQVCG SSLWIWLAAI LGISAMNMLI
GILIGCSIVS ILLIFSVTPN RSVAEHEEIP YQSRP
