ID   MDTO_ECOL6              Reviewed;         683 AA.
AC   Q8FAX2;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Multidrug resistance protein MdtO;
GN   Name=mdtO; OrderedLocusNames=c5086;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Could be involved in resistance to puromycin, acriflavine and
CC       tetraphenylarsonium chloride. {ECO:0000250}.
CC   -!- SUBUNIT: Could be part of a tripartite efflux system composed of MdtN,
CC       MdtO and MdtP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MdtO family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN83511.1; -; Genomic_DNA.
DR   RefSeq; WP_001275175.1; NC_004431.1.
DR   AlphaFoldDB; Q8FAX2; -.
DR   STRING; 199310.c5086; -.
DR   EnsemblBacteria; AAN83511; AAN83511; c5086.
DR   KEGG; ecc:c5086; -.
DR   eggNOG; COG1289; Bacteria.
DR   HOGENOM; CLU_023392_1_0_6; -.
DR   OMA; QSDWRIT; -.
DR   BioCyc; ECOL199310:C5086-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR   Pfam; PF04632; FUSC; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell inner membrane; Cell membrane; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..683
FT                   /note="Multidrug resistance protein MdtO"
FT                   /id="PRO_0000210090"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        483..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   683 AA;  76268 MW;  0413891A0E01DB05 CRC64;
     MSALNSLPLP VVRLLAFFHE ELSERRPGRV PQTMQLWVGC LLVILISMTF EIPFVALSLA
     VLFYGIQSNA FYTKFVAILF VVATVLEIAS LFLIYKWSYG EPLIRLIIAG PILMSCMFLM
     RTHRLGLVFF AVAIVAIYGQ TFPAMLDYPE AVVRLTLWCI VVGLYPTLLM TLIGVLWFPS
     RAITQMHQAL NDRLDDAISH LTDSLAPLPE TRIEREALAL QKLNVFCLAD DANWRTQSAW
     WQSCVATVTY IYSTLNRYDP TSFADSQAII EFRQKLASEI NKLQHSITEG QCWQSDWRIS
     ESEAMTAREC NLENICQTLL QLGQMDPNTP PTPAAKPPSM VADAFTNPDY MRYAVKTLLA
     CLICYTFYSG VDWEGIHTCM LTCVIVANPN VGSSYQKMVL RFGGAFCGAI LALLFTLLVM
     PWLDNIVELL FVLAPIFLLG AWIATSSERS SYIGTQMVVT FALATLENVF GPVYDLVEIR
     DRALGIIIGT VVSAVIYTFV WPESEARTLP QKLAGALGML SKVMRIPRQQ EVTALRTYLH
     IRIGLHAAFN ACEEMCQRVV LERQLDSEER ALLIERSQTV IRQGRDILHA WDATWNSAQA
     LDNALQPDRA GQFADALEKY AAGVATALSH SPQITLEETS ASQAILPTLL KQEQHVCQLF
     ARLPDWTAPA LTPATEQAQG ATQ