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MDTO_ECOLI
ID   MDTO_ECOLI              Reviewed;         683 AA.
AC   P32715; Q2M6M3;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 157.
DE   RecName: Full=Multidrug resistance protein MdtO;
GN   Name=mdtO; Synonyms=yjcQ; OrderedLocusNames=b4081, JW4042;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA   Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.;
RT   "Analysis of the Escherichia coli genome. IV. DNA sequence of the region
RT   from 89.2 to 92.8 minutes.";
RL   Nucleic Acids Res. 21:5408-5417(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   PUTATIVE FUNCTION.
RX   PubMed=11257026; DOI=10.1128/aac.45.4.1126-1136.2001;
RA   Sulavik M.C., Houseweart C., Cramer C., Jiwani N., Murgolo N., Greene J.,
RA   DiDomenico B., Shaw K.J., Miller G.H., Hare R., Shimer G.;
RT   "Antibiotic susceptibility profiles of Escherichia coli strains lacking
RT   multidrug efflux pump genes.";
RL   Antimicrob. Agents Chemother. 45:1126-1136(2001).
RN   [5]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
RN   [6]
RP   OPERON STRUCTURE, AND INDUCTION.
RC   STRAIN=K12 / BW25113;
RX   PubMed=19429622; DOI=10.1128/jb.00108-09;
RA   Shimada T., Yamamoto K., Ishihama A.;
RT   "Involvement of the leucine response transcription factor LeuO in
RT   regulation of the genes for sulfa drug efflux.";
RL   J. Bacteriol. 191:4562-4571(2009).
CC   -!- FUNCTION: Could be involved in resistance to puromycin, acriflavine and
CC       tetraphenylarsonium chloride.
CC   -!- SUBUNIT: Could be part of a tripartite efflux system composed of MdtN,
CC       MdtO and MdtP.
CC   -!- INTERACTION:
CC       P32715; P76237: dgcJ; NbExp=2; IntAct=EBI-555775, EBI-555763;
CC       P32715; P07395: pheT; NbExp=4; IntAct=EBI-555775, EBI-555713;
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000305|PubMed:15919996}; Multi-pass membrane protein
CC       {ECO:0000305|PubMed:15919996}.
CC   -!- INDUCTION: Induced by LeuO, part of the mdtNO operon.
CC       {ECO:0000269|PubMed:19429622}.
CC   -!- SIMILARITY: Belongs to the MdtO family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC43175.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U00006; AAC43175.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAD13464.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78083.1; -; Genomic_DNA.
DR   PIR; H65216; H65216.
DR   RefSeq; NP_418505.2; NC_000913.3.
DR   RefSeq; WP_001275207.1; NZ_LN832404.1.
DR   AlphaFoldDB; P32715; -.
DR   BioGRID; 4262952; 6.
DR   BioGRID; 852876; 3.
DR   ComplexPortal; CPX-6021; SdsRQP multidrug transport complex.
DR   DIP; DIP-12556N; -.
DR   IntAct; P32715; 3.
DR   STRING; 511145.b4081; -.
DR   TCDB; 2.A.85.6.1; the aromatic acid exporter (arae) family.
DR   PaxDb; P32715; -.
DR   PRIDE; P32715; -.
DR   EnsemblBacteria; AAD13464; AAD13464; b4081.
DR   EnsemblBacteria; BAE78083; BAE78083; BAE78083.
DR   GeneID; 948582; -.
DR   KEGG; ecj:JW4042; -.
DR   KEGG; eco:b4081; -.
DR   PATRIC; fig|1411691.4.peg.2620; -.
DR   EchoBASE; EB1896; -.
DR   eggNOG; COG1289; Bacteria.
DR   HOGENOM; CLU_023392_1_0_6; -.
DR   OMA; QSDWRIT; -.
DR   BioCyc; EcoCyc:YJCQ-MON; -.
DR   BioCyc; MetaCyc:YJCQ-MON; -.
DR   PRO; PR:P32715; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:1990351; C:transporter complex; IC:ComplexPortal.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR   Pfam; PF04632; FUSC; 1.
PE   1: Evidence at protein level;
KW   Antibiotic resistance; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..683
FT                   /note="Multidrug resistance protein MdtO"
FT                   /id="PRO_0000210089"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        483..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   683 AA;  76151 MW;  F9BE67EE4E01921C CRC64;
     MSALNSLPLP VVRLLAFFHE ELSERRPGRV PQTVQLWVGC LLVILISMTF EIPFVALSLA
     VLFYGIQSNA FYTKFVAILF VVATVLEIGS LFLIYKWSYG EPLIRLIIAG PILMGCMFLM
     RTHRLGLVFF AVAIVAIYGQ TFPAMLDYPE VVVRLTLWCI VVGLYPTLLM TLIGVLWFPS
     RAISQMHQAL NDRLDDAISH LTDSLAPLPE TRIEREALAL QKLNVFCLAD DANWRTQNAW
     WQSCVATVTY IYSTLNRYDP TSFADSQAII EFRQKLASEI NKLQHAVAEG QCWQSDWRIS
     ESEAMAAREC NLENICQTLL QLGQMDPNTP PTPAAKPPSM AADAFTNPDY MRYAVKTLLA
     CLICYTFYSG VDWEGIHTCM LTCVIVANPN VGSSYQKMVL RFGGAFCGAI LALLFTLLVM
     PWLDNIVELL FVLAPIFLLG AWIATSSERS SYIGTQMVVT FALATLENVF GPVYDLVEIR
     DRALGIIIGT VVSAVIYTFV WPESEARTLP QKLAGTLGML SKVMRIPRQQ EVTALRTYLQ
     IRIGLHAAFN ACEEMCQRVA LERQLDSEER ALLIERSQTV IRQGRDLLHA WDATWNSAQA
     LDNALQPDRA GQFADALEKY AAGLATALSR SPQITLEETP ASQAILPTLL KQEQHVCQLF
     ARLPDWTAPA LTPATEQAQG ATQ
 
 
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