ID   MDTP_ECO57              Reviewed;         488 AA.
AC   Q8X5R9; Q7A915;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Multidrug resistance outer membrane protein MdtP;
DE   Flags: Precursor;
GN   Name=mdtP; OrderedLocusNames=Z5680, ECs5062;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Could be involved in resistance to puromycin, acriflavine and
CC       tetraphenylarsonium chloride. {ECO:0000250}.
CC   -!- SUBUNIT: Could be part of a tripartite efflux system composed of MdtN,
CC       MdtO and MdtP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC       family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG59278.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38485.1; -; Genomic_DNA.
DR   PIR; B86102; B86102.
DR   PIR; F91261; F91261.
DR   RefSeq; NP_313089.1; NC_002695.1.
DR   RefSeq; WP_000610591.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X5R9; -.
DR   SMR; Q8X5R9; -.
DR   STRING; 155864.EDL933_5422; -.
DR   EnsemblBacteria; AAG59278; AAG59278; Z5680.
DR   EnsemblBacteria; BAB38485; BAB38485; ECs_5062.
DR   GeneID; 914272; -.
DR   KEGG; ece:Z5680; -.
DR   KEGG; ecs:ECs_5062; -.
DR   PATRIC; fig|386585.9.peg.5290; -.
DR   eggNOG; COG1538; Bacteria.
DR   HOGENOM; CLU_012817_6_3_6; -.
DR   OMA; MSMNYAL; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR003423; OMP_efflux.
DR   InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR   Pfam; PF02321; OEP; 2.
DR   TIGRFAMs; TIGR01845; outer_NodT; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell outer membrane; Lipoprotein; Membrane;
KW   Palmitate; Reference proteome; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           24..488
FT                   /note="Multidrug resistance outer membrane protein MdtP"
FT                   /id="PRO_0000031010"
FT   LIPID           24
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           24
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   488 AA;  53510 MW;  0ED969C6F4A7975C CRC64;
     MINRQLSRLL LCSILGSTTL ISGCALVRKD SAPHQQLKPE QIKLADDIHL ASSGWPQAQW
     WKQLNDPQLD ALIQRTLSGS HTLAEAKLRE EKAQSQADLL DAGSQLQVAA LGMLNRQRVS
     ANGFLSPYAM DAPALGMDGP YYTEATVGLF AGLDLDLWGV HRSAVTAAIG AHNAALAETA
     AVELSLTTGV AQLYYSMQAS YQMLDLLEQT RDVIDYAVKA HQSKVAHGLE AQVPFHGARA
     QILAVDKQIA AVKGQITETR ESLRALIGAG ASDMPEIKPV ALPRVQTGIP ATLSYELLAR
     RPDLQAMRWY VQASLDQVDS ARALFYPSFD IKAFFGLDSI HLDTLFKKTS RQFNFIPGLK
     LPLFDGGRLN ANLEGTRAAS NMMIERYNQS VLNAVRDVAV NGTRLQTLND EREMQAERVE
     ATRFTQRAAE AAYQRGLTSR LQATEARLPV LAEEMSLLML DSRRVIQSIQ LMKSLGSGYQ
     AAPVVEKK