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MDTP_ECOLI
ID   MDTP_ECOLI              Reviewed;         488 AA.
AC   P32714; Q2M6M4;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Multidrug resistance outer membrane protein MdtP;
DE   Flags: Precursor;
GN   Name=mdtP; Synonyms=yjcP; OrderedLocusNames=b4080, JW4041;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA   Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.;
RT   "Analysis of the Escherichia coli genome. IV. DNA sequence of the region
RT   from 89.2 to 92.8 minutes.";
RL   Nucleic Acids Res. 21:5408-5417(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP   170.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION.
RX   PubMed=11257026; DOI=10.1128/aac.45.4.1126-1136.2001;
RA   Sulavik M.C., Houseweart C., Cramer C., Jiwani N., Murgolo N., Greene J.,
RA   DiDomenico B., Shaw K.J., Miller G.H., Hare R., Shimer G.;
RT   "Antibiotic susceptibility profiles of Escherichia coli strains lacking
RT   multidrug efflux pump genes.";
RL   Antimicrob. Agents Chemother. 45:1126-1136(2001).
CC   -!- FUNCTION: Could be involved in resistance to puromycin, acriflavine and
CC       tetraphenylarsonium chloride. {ECO:0000269|PubMed:11257026}.
CC   -!- SUBUNIT: Could be part of a tripartite efflux system composed of MdtN,
CC       MdtO and MdtP.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC       family. {ECO:0000305}.
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DR   EMBL; U00006; AAC43174.1; -; Genomic_DNA.
DR   EMBL; U00096; AAD13463.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78082.1; -; Genomic_DNA.
DR   PIR; G65216; G65216.
DR   RefSeq; NP_418504.1; NC_000913.3.
DR   RefSeq; WP_000610601.1; NZ_SSZK01000016.1.
DR   AlphaFoldDB; P32714; -.
DR   SMR; P32714; -.
DR   BioGRID; 4262951; 161.
DR   ComplexPortal; CPX-6021; SdsRQP multidrug transport complex.
DR   IntAct; P32714; 3.
DR   STRING; 511145.b4080; -.
DR   TCDB; 1.B.17.3.9; the outer membrane factor (omf) family.
DR   PaxDb; P32714; -.
DR   PRIDE; P32714; -.
DR   EnsemblBacteria; AAD13463; AAD13463; b4080.
DR   EnsemblBacteria; BAE78082; BAE78082; BAE78082.
DR   GeneID; 948583; -.
DR   KEGG; ecj:JW4041; -.
DR   KEGG; eco:b4080; -.
DR   PATRIC; fig|1411691.4.peg.2621; -.
DR   EchoBASE; EB1895; -.
DR   eggNOG; COG1538; Bacteria.
DR   HOGENOM; CLU_012817_6_3_6; -.
DR   InParanoid; P32714; -.
DR   OMA; MSMNYAL; -.
DR   PhylomeDB; P32714; -.
DR   BioCyc; EcoCyc:EG11952-MON; -.
DR   BioCyc; MetaCyc:EG11952-MON; -.
DR   PRO; PR:P32714; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR   GO; GO:1990351; C:transporter complex; IC:ComplexPortal.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IMP:EcoCyc.
DR   GO; GO:0055085; P:transmembrane transport; IC:ComplexPortal.
DR   InterPro; IPR003423; OMP_efflux.
DR   InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR   Pfam; PF02321; OEP; 2.
DR   TIGRFAMs; TIGR01845; outer_NodT; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell outer membrane; Lipoprotein; Membrane;
KW   Palmitate; Reference proteome; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           24..488
FT                   /note="Multidrug resistance outer membrane protein MdtP"
FT                   /id="PRO_0000031009"
FT   LIPID           24
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           24
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CONFLICT        170
FT                   /note="G -> A (in Ref. 1; AAC43174)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   488 AA;  53453 MW;  C281EEDDD8595ADA CRC64;
     MINRQLSRLL LCSILGSTTL ISGCALVRKD SAPHQQLKPE QIKLADDIHL ASSGWPQAQW
     WKQLNDPQLD ALIQRTLSGS HTLAEAKLRE EKAQSQADLL DAGSQLQVAA LGMLNRQRVS
     ANGFLSPYSM DAPALGMDGP YYTEATVGLF AGLDLDLWGV HRSAVAAAIG AHNAALAETA
     AVELSLATGV AQLYYSMQAS YQMLDLLEQT HDVIDYAVKA HQSKVAHGLE AQVPFHGARA
     QILAVDKQIV AVKGQITETR ESLRALIGAG ASDMPEIRPV ALPQVQTGIP ATLSYELLAR
     RPDLQAMRWY VQASLDQVDS ARALFYPSFD IKAFFGLDSI HLHTLFKKTS RQFNFIPGLK
     LPLFDGGRLN ANLEGTRAAS NMMIERYNQS VLNAVRDVAV NGTRLQTLND EREMQAERVE
     ATRFTQRAAE AAYQRGLTSR LQATEARLPV LAEEMSLLML DSRRVIQSIQ LMKSLGGGYQ
     AGPVVEKK
 
 
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