ID   MDTQ_ECO57              Reviewed;         478 AA.
AC   Q8X659; Q7ACA2;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 3.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Multidrug resistance outer membrane protein MdtQ;
DE   Flags: Precursor;
GN   Name=mdtQ; OrderedLocusNames=Z3387, ECs3025;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Could be involved in resistance to puromycin, acriflavine and
CC       tetraphenylarsonium chloride. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG57270.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB36448.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG57270.2; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB36448.1; ALT_INIT; Genomic_DNA.
DR   PIR; A98007; A98007.
DR   PIR; B85851; B85851.
DR   RefSeq; NP_311052.2; NC_002695.1.
DR   RefSeq; WP_001078131.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X659; -.
DR   SMR; Q8X659; -.
DR   STRING; 155864.EDL933_3294; -.
DR   EnsemblBacteria; AAG57270; AAG57270; Z3387.
DR   EnsemblBacteria; BAB36448; BAB36448; ECs_3025.
DR   GeneID; 916729; -.
DR   KEGG; ece:Z3387; -.
DR   KEGG; ecs:ECs_3025; -.
DR   PATRIC; fig|386585.9.peg.3150; -.
DR   eggNOG; COG1538; Bacteria.
DR   HOGENOM; CLU_012817_6_3_6; -.
DR   OMA; DQFYGPG; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR003423; OMP_efflux.
DR   InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR   Pfam; PF02321; OEP; 2.
DR   TIGRFAMs; TIGR01845; outer_NodT; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell outer membrane; Lipoprotein; Membrane;
KW   Palmitate; Reference proteome; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           22..478
FT                   /note="Multidrug resistance outer membrane protein MdtQ"
FT                   /id="PRO_0000031014"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   478 AA;  52189 MW;  1BE62D695CB1C453 CRC64;
     MNRDSFYPAI ACFPLLLMLA GCAPMHETRQ ALSQQTPAAQ VDTALPTALK NGWPDSQWWL
     EYHDNQLTSL INNALQNAPD MQVAEQRIQL AEAQAKAVAT QDGPQIDFSA DMERQKMSAE
     GLMGPFALND PAAGTTGPWY TNGTFGLTAG WHLDIWGKNR AEVTARLGTV KARAAEREQT
     RQLLAGSVAR LYWEWQTQAA LNTVLQQIEK EQNTIIATDR QLYQNGITSS VEGVETDINA
     SKTRQQLNDV AGKMKIIEAR LIALTNHQTK SLTLKPVALP KVASQLPDEL GYSLLARRAD
     LQAAHWYVES SLSTIDAAKA AFYPDINLMA FLQQDALHLS DLFRHSAQQM GVTAGLTLPI
     FDSGRLNANL DIAKAESNLS IASYNKAVVE AVNDVARAAS QVQTLAEKNQ HQAQIERDAL
     RVVGLAQARF NAGIIAGSRV SEARIPALRE RANGLLLQGQ WLDASIQLTG ALGGGYKR