ID   MDTQ_ECOL6              Reviewed;         478 AA.
AC   Q8FFV6;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Multidrug resistance outer membrane protein MdtQ;
DE   Flags: Precursor;
GN   Name=mdtQ; OrderedLocusNames=c2671;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Could be involved in resistance to puromycin, acriflavine and
CC       tetraphenylarsonium chloride. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN81127.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN81127.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001078151.1; NZ_CP051263.1.
DR   AlphaFoldDB; Q8FFV6; -.
DR   SMR; Q8FFV6; -.
DR   STRING; 199310.c2671; -.
DR   EnsemblBacteria; AAN81127; AAN81127; c2671.
DR   KEGG; ecc:c2671; -.
DR   eggNOG; COG1538; Bacteria.
DR   HOGENOM; CLU_012817_6_3_6; -.
DR   OMA; DQFYGPG; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR003423; OMP_efflux.
DR   InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR   Pfam; PF02321; OEP; 2.
DR   TIGRFAMs; TIGR01845; outer_NodT; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell outer membrane; Lipoprotein; Membrane;
KW   Palmitate; Signal; Transmembrane; Transmembrane beta strand.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           22..478
FT                   /note="Multidrug resistance outer membrane protein MdtQ"
FT                   /id="PRO_0000031015"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   478 AA;  52208 MW;  3A125809FD6B3245 CRC64;
     MNRDSFYPAI ACFPLLLMLA GCAPMHETRQ ALSQQTPAAQ VDTALPTALK NGWPDSQWWL
     EYHDNQLTSL INNALQSAPD MQVAEQRIQL AEAQAKAVAT QDGPQLDFSA DMERQKMSAE
     GLMGPFALND PAAGTTGPWY TNGTFGLTAG WHLDIWGKNR AEITARLGTV KARAAEREQT
     RQLLAGSVAR LYWEWQTQAA LNTVLQQIEK EQNTIIATDR QLYQNGITSS VEGVETDINA
     SKTRQQLNDV AGKMKIIEAR LNALTNHQTK SLKLKTVALP KVASQLPDEL GYSLLARRAD
     LQAAHWYVES SLSTIDAAKA AFYPDINLMA FLQQDALHLS DLFRHSAQQM GVTAGLTLPI
     FDSGRLNANL DIAKAESNLS IASYNKAVVE AVNDVARAAS QVQTLAEKNQ HQAQIERDAL
     RVVGLAQARF NAGLIAGSRV SEARIPALRE RANGLLLQGQ WLDASIQLTG ALGGGYKR