MDTQ_ECOLI
ID MDTQ_ECOLI Reviewed; 478 AA.
AC P33369; P33370; Q2MAU0; Q2MAU1;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 07-OCT-2020, entry version 146.
DE RecName: Full=Putative multidrug resistance outer membrane protein MdtQ;
DE Flags: Precursor;
GN Name=mdtQ; Synonyms=yohG, yohH; OrderedLocusNames=b2139, JW5838/JW5358;
GN ORFNames=b2138;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / BHB2600;
RA Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA Church G.M.;
RT "Automated multiplex sequencing of the E.coli genome.";
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP CONCEPTUAL TRANSLATION.
RA Rudd K.E.;
RL Unpublished observations (JUN-1999).
RN [5]
RP FUNCTION.
RX PubMed=11257026; DOI=10.1128/aac.45.4.1126-1136.2001;
RA Sulavik M.C., Houseweart C., Cramer C., Jiwani N., Murgolo N., Greene J.,
RA DiDomenico B., Shaw K.J., Miller G.H., Hare R., Shimer G.;
RT "Antibiotic susceptibility profiles of Escherichia coli strains lacking
RT multidrug efflux pump genes.";
RL Antimicrob. Agents Chemother. 45:1126-1136(2001).
CC -!- FUNCTION: Could be involved in resistance to puromycin, acriflavine and
CC tetraphenylarsonium chloride. {ECO:0000269|PubMed:11257026}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA60501.1; Type=Frameshift; Note=Produces two separate ORFs.; Evidence={ECO:0000305};
CC Sequence=AAA60502.1; Type=Frameshift; Note=Produces two separate ORFs.; Evidence={ECO:0000305};
CC Sequence=BAE76615.1; Type=Frameshift; Note=Produces two separate ORFs.; Evidence={ECO:0000305};
CC Sequence=BAE76616.1; Type=Frameshift; Note=Produces two separate ORFs.; Evidence={ECO:0000305};
CC Sequence=U00096; Type=Frameshift; Note=Produces two separate ORFs.; Evidence={ECO:0000305};
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DR EMBL; U00007; AAA60501.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00007; AAA60502.1; ALT_SEQ; Genomic_DNA.
DR EMBL; U00096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP009048; BAE76615.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AP009048; BAE76616.1; ALT_SEQ; Genomic_DNA.
DR PIR; A64982; A64982.
DR PIR; B64982; B64982.
DR BioGRID; 4260455; 240.
DR BioGRID; 4260456; 78.
DR IntAct; P33369; 1.
DR STRING; 316407.85675252; -.
DR TCDB; 1.B.17.3.10; the outer membrane factor (omf) family.
DR PRIDE; P33369; -.
DR EnsemblBacteria; BAE76615; BAE76615; BAE76615.
DR EnsemblBacteria; BAE76616; BAE76616; BAE76616.
DR KEGG; ecj:JW5358; -.
DR KEGG; ecj:JW5838; -.
DR EchoBASE; EB1956; -.
DR eggNOG; COG1538; Bacteria.
DR HOGENOM; CLU_012817_6_0_6; -.
DR InParanoid; P33369; -.
DR PhylomeDB; P33369; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR InterPro; IPR003423; OMP_efflux.
DR InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR Pfam; PF02321; OEP; 2.
DR TIGRFAMs; TIGR01845; outer_NodT; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 5: Uncertain;
KW Antibiotic resistance; Cell outer membrane; Lipoprotein; Membrane;
KW Palmitate; Reference proteome; Signal; Transmembrane;
KW Transmembrane beta strand.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 22..478
FT /note="Putative multidrug resistance outer membrane protein
FT MdtQ"
FT /id="PRO_0000031013"
FT LIPID 22
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 22
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 478 AA; 52138 MW; 32C92C44193C9CFF CRC64;
MNRDSFYPAI ACFPLLLMLA GCAPMHETRQ ALSQQTPAAQ VDTALPTALK MVGQTXQWWL
EYHDNQLTSL INNALQNAPD MQVAEQRIQL AEAQAKAVAT QDGPQIDFSA DMERQKMSAE
GLMGPFALND PAAGTTGPWY TNGTFGLTAG WHLDIWGKNR AEVTARLGTV KARAAEREQT
RQLLAGSVAR LYWEWQTQAA LNTVLQQIEK EQNTIIATDR QLYQNGITSS VEGVETDINA
SKTRQQLNDV AGKMKIIEAR LSALTNNQTK SLKLKPVALP KVASQLPDEL GYSLLARRAD
LQAAHWYVES SLSTIDAAKA AFYPDINLMA FLQQDALHLS DLFRHSAQQM GVTAGLTLPI
FDSGRLNANL DIAKAESNLS IASYNKAVVE AVNDVARAAS QVQTLAEKNQ HQAQIERDAL
RVVGLAQARF NAGIIAGSRV SEARIPALRE RANGLLLQGQ WLDASIQLTG ALGGGYKR
