ID   MDV1_ASPCL              Reviewed;         655 AA.
AC   A1CBP8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Mitochondrial division protein 1;
GN   Name=mdv1; ORFNames=ACLA_016120;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC       required to form mitochondrial fission complexes. Formation of these
CC       complexes is required to promote constriction and fission of the
CC       mitochondrial compartment at a late step in mitochondrial division (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR   EMBL; DS027049; EAW13166.1; -; Genomic_DNA.
DR   RefSeq; XP_001274592.1; XM_001274591.1.
DR   AlphaFoldDB; A1CBP8; -.
DR   SMR; A1CBP8; -.
DR   STRING; 5057.CADACLAP00001086; -.
DR   EnsemblFungi; EAW13166; EAW13166; ACLA_016120.
DR   GeneID; 4706555; -.
DR   KEGG; act:ACLA_016120; -.
DR   VEuPathDB; FungiDB:ACLA_016120; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   HOGENOM; CLU_012350_1_1_1; -.
DR   OMA; IVGVWTC; -.
DR   OrthoDB; 927943at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..655
FT                   /note="Mitochondrial division protein 1"
FT                   /id="PRO_0000330096"
FT   REPEAT          317..358
FT                   /note="WD 1"
FT   REPEAT          359..396
FT                   /note="WD 2"
FT   REPEAT          434..473
FT                   /note="WD 3"
FT   REPEAT          479..536
FT                   /note="WD 4"
FT   REPEAT          539..578
FT                   /note="WD 5"
FT   REPEAT          580..615
FT                   /note="WD 6"
FT   REPEAT          626..655
FT                   /note="WD 7"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          199..244
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        245..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   655 AA;  72298 MW;  DED2227B726A2950 CRC64;
     MAKQRRDESP SGLSDIVEPD GLLGTGLTSR HIEAFGRKVT STAGHLMGPT TESSNGGHYH
     TAMVDIHREL RRPTTQRKVF SLTQTTPTDL VRSKLSTTEI QSRAISSLPD ELLANIPEDS
     SSYSLFEGFK ATQDDHEYRK SHRRRSSKAK KLLKDGQAKE ALPSAPTDLK KDRDLLSRRL
     DLMGVRKNMC SSEIHDIDNK IANLHNMRKI VLERLAGLEM EEAELEHELT EIDNKLEDIQ
     EDTPGTPVAV STPKSSEAAD DSVLSEDSAM DASFMSESIY QKLPSPKSLK KRSIRKRSMP
     ILHEHFSPGS QIKEMQAHTD MVTAIDFDYP FGTMVSAALD DTVRVWDLNT GRCMGFLEGH
     NASVRCLQVE DNIVATGSMD ASVKLWDLSR ARTVPRDNRV GRPDEEDEED DGTDAFSILS
     ATTLEDCYVF SLDAHVDEVT ALHFRGDTLI SGSADKTLRQ WDLVKGRCVQ TLDVLWAAAQ
     ASTIGADTQW RPSGRLPDAS ADFVGAVQCF DAALACGTAD GMVRLWDLRS GQVHRSLVGH
     TGPITCLQFD EVHLVTGSQD RSIRIWDLRM GSIFDAFAYE KPITSMMFDT KRIVAAAGEN
     VVKVYDKADS NHWDCGAGLG ADEVGPAPAT VERVRLKDGY LLEGRKDGIV AAWTC