MDV1_ASPFU
ID MDV1_ASPFU Reviewed; 658 AA.
AC Q4WVS4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Mitochondrial division protein 1;
GN Name=mdv1; ORFNames=AFUA_5G13140;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC required to form mitochondrial fission complexes. Formation of these
CC complexes is required to promote constriction and fission of the
CC mitochondrial compartment at a late step in mitochondrial division (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL91302.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHF01000003; EAL91302.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_753340.1; XM_748247.1.
DR AlphaFoldDB; Q4WVS4; -.
DR SMR; Q4WVS4; -.
DR STRING; 330879.Q4WVS4; -.
DR GeneID; 3511496; -.
DR KEGG; afm:AFUA_5G13140; -.
DR VEuPathDB; FungiDB:Afu5g13140; -.
DR InParanoid; Q4WVS4; -.
DR OrthoDB; 927943at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central.
DR GO; GO:0016559; P:peroxisome fission; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..658
FT /note="Mitochondrial division protein 1"
FT /id="PRO_0000330097"
FT REPEAT 319..360
FT /note="WD 1"
FT REPEAT 361..398
FT /note="WD 2"
FT REPEAT 437..476
FT /note="WD 3"
FT REPEAT 482..539
FT /note="WD 4"
FT REPEAT 542..581
FT /note="WD 5"
FT REPEAT 583..618
FT /note="WD 6"
FT REPEAT 629..658
FT /note="WD 7"
FT REGION 139..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 209..246
FT /evidence="ECO:0000255"
SQ SEQUENCE 658 AA; 72325 MW; 9F96872B44184FE7 CRC64;
MATQRRDESP SGLSDIVEPD GLLGIGLTSR HIEAFGRKVT STAGHLMGPI TDSSNGSHYH
TAMADIHREL RRPTTQRKVF SLTQTSPTDL VRSKLSTSEI QSRALSSVPD ELLANIPEDS
SSYSLFEGFK ATQDDHEFRK AHRRRSSKGK KLLKDGEAAG ALPSAPTDLK KERDLLSRRL
DLMGVRKNMC SSEIHEIDNK IANLHNIRKI VLDRLAGLEM EEAELEHQLT EIDNKLEDIQ
EEAPKTPLTA ATPKSSSVND DSVVSEDAAL DASFMSESIY QKLPSHSPRS LKQRSIRKRS
MPILHEHFAP GSQIKEMQAH TDMVTAIDFD YPFGTMVSAA LDDTVRVWDL NTGRCTGFLE
GHNASVRCLQ VEDNIVATGS MDASVKLWDL SRARTVTRDN RLNKPSEGEG EDDNASDAFS
LFSATTLEDC YVFSLDAHVD EVTALHFRGN TLISGSADKT LRQWDLVKGR CVQTLDVLWA
AAQASTLAAD TQWRPSGRLP DASADFVGAL QCFDAALACG TADGMVRLWD LRSGQVHRSL
VGHTGPITCL QFDEVHLVTG SQDRSIRIWD LRMGSIFDAY AYDKPITSMM FDTKRIVAAA
GENVVKVYDK ADGHHWDCGA GVGADESGPA PATVERVRLK DGYLLEGRKD GTVAAWTC
