ID   MDV1_ASPOR              Reviewed;         650 AA.
AC   Q2U5Z8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Mitochondrial division protein 1;
GN   Name=mdv1; ORFNames=AO090120000439;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC       required to form mitochondrial fission complexes. Formation of these
CC       complexes is required to promote constriction and fission of the
CC       mitochondrial compartment at a late step in mitochondrial division (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE63017.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP007166; BAE63017.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001824150.2; XM_001824098.2.
DR   AlphaFoldDB; Q2U5Z8; -.
DR   SMR; Q2U5Z8; -.
DR   STRING; 510516.Q2U5Z8; -.
DR   VEuPathDB; FungiDB:AO090120000439; -.
DR   Proteomes; UP000006564; Chromosome 5.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..650
FT                   /note="Mitochondrial division protein 1"
FT                   /id="PRO_0000330099"
FT   REPEAT          314..355
FT                   /note="WD 1"
FT   REPEAT          356..393
FT                   /note="WD 2"
FT   REPEAT          429..468
FT                   /note="WD 3"
FT   REPEAT          474..531
FT                   /note="WD 4"
FT   REPEAT          534..573
FT                   /note="WD 5"
FT   REPEAT          575..610
FT                   /note="WD 6"
FT   REPEAT          617..650
FT                   /note="WD 7"
FT   REGION          241..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          393..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          207..247
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        246..260
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..410
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   650 AA;  71705 MW;  F01EBAB0D62F9626 CRC64;
     MDKHRRDESP SGLSDIVEHD GLLGTGLTTR HIEAFGRKVT STAGHLIGPT GDGNPAHYHN
     AMADIQRELR RPNTQRRVFA LTQTTPTDLV RSKLSTSEIQ SRALSSLPDD LLANIPDDSS
     SYSLFEGFQA SQDDIEYRKA HRRRASKSKK LLKDGENRAA LPSAPAELKK ERDLLSRRME
     LMGVRKNMCS SEIHDIDNKI ANLHNMRKIV LDRLAGLEME EAELEHELTE LENKLEDIQE
     ETPETAVVGT PKSSANDESM ASEDPAMDAS FMSESIYQKI PSPKSLKHKS KRKRSMPILH
     EHFSPGSLIK EMEAHTDMVT AIDFDYPFGT MITAALDDTV RVWDLNVGRC TGFLEGHNAS
     VRCLQIEDNI VATGSMDASV KLWDLSRARS RPRSSRINKH EDEEDAADDA SQVSHSTTLE
     DCHVFSLDSH VGEVTALHFR GDNLISGSAD KTLRQWDLVK GRCVQTLDVL WAAAQADTLN
     GDSTWRPSGR VPDASADFVG ALQCFDAALA CGTADGMVRL WDLRSGQVHR SLVGHTGPVT
     CLQFDDVHLV TGSMDRSIRI WDLRMGSIYD AFAYDKPVTS MKFDAKRIVA AAGESVVKVY
     DKADGNHWDC GAGVGADEQG PLPATVDRVC LKDGFLVEGR QDGIVGAWTC