ID   MDV1_CHAGB              Reviewed;         657 AA.
AC   Q2H139;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Mitochondrial division protein 1;
GN   Name=MDV1; ORFNames=CHGG_04507;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC       required to form mitochondrial fission complexes. Formation of these
CC       complexes is required to promote constriction and fission of the
CC       mitochondrial compartment at a late step in mitochondrial division (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAQ87888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAQ87888.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CH408032; EAQ87888.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001223721.1; XM_001223720.1.
DR   AlphaFoldDB; Q2H139; -.
DR   SMR; Q2H139; -.
DR   STRING; 38033.XP_001223721.1; -.
DR   EnsemblFungi; EAQ87888; EAQ87888; CHGG_04507.
DR   GeneID; 4392468; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   HOGENOM; CLU_012350_1_1_1; -.
DR   InParanoid; Q2H139; -.
DR   OrthoDB; 927943at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..657
FT                   /note="Mitochondrial division protein 1"
FT                   /id="PRO_0000330102"
FT   REPEAT          314..355
FT                   /note="WD 1"
FT   REPEAT          356..393
FT                   /note="WD 2"
FT   REPEAT          435..474
FT                   /note="WD 3"
FT   REPEAT          495..538
FT                   /note="WD 4"
FT   REPEAT          541..578
FT                   /note="WD 5"
FT   REPEAT          580..617
FT                   /note="WD 6"
FT   REPEAT          626..657
FT                   /note="WD 7"
FT   REGION          245..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          211..249
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        245..261
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   657 AA;  72844 MW;  A6D0374784022DBA CRC64;
     MDDPGHDNEF PDLSSFDDES SVISTRGLEA FGRKVTTTAA HLIAPRADPA SNPTYQTAMT
     EVHRQLRRPG LQRSMFSMAR TTPTDMVRSR LSTKEIQSRA LAYVPDELLQ NIPDGDSSYS
     LFQGFQASFP DFTEEGKKHR RRVSRGRKLL DEGPTIPDGT PESVQRLKKE KASMMHQFEM
     LGIRKNMASS EIREIDAKME NLAGMRRIIL ERLATLEQDE AILEHDIVEV EGRLEEAQEL
     ANEAGELAHT PKSEDDAASE KGDTPGFMSQ SVYEKLPSVG STSSKKKPRS IRRKTMPILH
     EHFEPGTMIR SMRAHHDSIT ALDFDAPFGL MVTAAMDDAV RVWDLNAGRC IGVLEGHTAS
     VRTLQVEDNF LATGSMDATI RLWDLSKAHY DPQGSQFGKD DEDDEDAIAF ENPDDHPVDP
     PAGSMSDCPL FTLEAHLDEI TALHFRNNVL VSGSADKTLR QWDLEKGRCV QTLDVMWAAA
     QASALSTSDS TWRQTSRAPD TAADFVGALQ VFESALACGT ADGMVRLWDL RSGQVSRSLV
     GHTGPVTCLQ FDDVHLVTGS LDRSIRIWDL RTGSSTTPLR TTTPITSMMF DTRRIVCAAG
     EDVVKVYDKV EGRHWDCGAG AVETEQEREP AVVERVRIRD GYMVEGRQDG IVGVWTC