ID   MDV1_COCIM              Reviewed;         668 AA.
AC   Q1DIW7; A0A0D8JT01; J3K0S3;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Mitochondrial division protein 1;
GN   Name=MDV1; ORFNames=CIMG_12420;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC       required to form mitochondrial fission complexes. Formation of these
CC       complexes is required to promote constriction and fission of the
CC       mitochondrial compartment at a late step in mitochondrial division (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR   EMBL; GG704912; KJF60417.1; -; Genomic_DNA.
DR   RefSeq; XP_012214191.1; XM_012358768.1.
DR   AlphaFoldDB; Q1DIW7; -.
DR   SMR; Q1DIW7; -.
DR   STRING; 246410.Q1DIW7; -.
DR   EnsemblFungi; KJF60417; KJF60417; CIMG_12420.
DR   GeneID; 24164129; -.
DR   KEGG; cim:CIMG_12420; -.
DR   VEuPathDB; FungiDB:CIMG_12420; -.
DR   InParanoid; Q1DIW7; -.
DR   OMA; IVGVWTC; -.
DR   OrthoDB; 927943at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..668
FT                   /note="Mitochondrial division protein 1"
FT                   /id="PRO_0000330103"
FT   REPEAT          323..364
FT                   /note="WD 1"
FT   REPEAT          365..402
FT                   /note="WD 2"
FT   REPEAT          445..484
FT                   /note="WD 3"
FT   REPEAT          490..549
FT                   /note="WD 4"
FT   REPEAT          552..591
FT                   /note="WD 5"
FT   REPEAT          593..628
FT                   /note="WD 6"
FT   REPEAT          634..668
FT                   /note="WD 7"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          137..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          193..259
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   668 AA;  74428 MW;  D7C553A7BFEBC4D0 CRC64;
     MADPQPRSDS PSGQSAVSHD EDEGSVLGTG LTTRHIEAFG RKVTTTASHL MAPKSDPTLT
     THYQSAMSDI QRELRRPTVQ RKVFSFAQTT PTDLVRSKLS TSEIQYRALS ALPDELLANI
     PEDTSTYSLF QGFQASMPED DNEHRKSHRR RRSHGQKLLE DSGKSSRPLP QTVGSLKRER
     DVLNRRLEMM GIRKNMCSAE IHEIDNKIAN LNNMRKIVLD RLAGLEMDEA ELEHELVQLD
     NRLEDMEEAM EESATLISTP KAVDDEVTLD SENQAMDASF MSESIYEKIP SPKAWKHKSL
     RKRSMPILHE HFEPGSMIRE LQAHNDMITA MDFDVPFGTM VSSALDDTVR VWDLNLGRCM
     GFLEGHHASV RCLQVENNIV ATGSMDASIR LWDLSRASYA PRDNRITRDD EEDDDDALGY
     EDPSAEPPPP PPSSMEDCPL FSLEAHVDEV TALHFRGDTL ISGSADKTLR QWDLVKGRCV
     QTLDVLWAAA QASSIMGGGD SQWRPTGRLP DASADFVGAL QCFDAALACG TADGMIRLWD
     LRSGQVHRSL VGHTGPITCL QFDDVHLITG SLDRSIRIWD LRTGSIYDAY AYDHPITSMM
     FDTRRIVAAA GEDVVKVYDK TDGRHWDCGA GVTAEEEGIT PAIVERVRIK DGYLTEGRKD
     GTIGIWTC