ID   MDV1_CRYNB              Reviewed;         757 AA.
AC   P0CS45; Q55K39; Q5K9G0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Mitochondrial division protein 1;
GN   Name=MDV1; OrderedLocusNames=CNBK1470;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC       required to form mitochondrial fission complexes. Formation of these
CC       complexes is required to promote constriction and fission of the
CC       mitochondrial compartment at a late step in mitochondrial division (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR   EMBL; AAEY01000052; EAL18126.1; -; Genomic_DNA.
DR   RefSeq; XP_772773.1; XM_767680.1.
DR   AlphaFoldDB; P0CS45; -.
DR   SMR; P0CS45; -.
DR   EnsemblFungi; AAW46166; AAW46166; CNK02070.
DR   EnsemblFungi; EAL18126; EAL18126; CNBK1470.
DR   GeneID; 4938843; -.
DR   KEGG; cnb:CNBK1470; -.
DR   VEuPathDB; FungiDB:CNBK1470; -.
DR   HOGENOM; CLU_012350_0_0_1; -.
DR   Proteomes; UP000001435; Chromosome 11.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane; Repeat;
KW   WD repeat.
FT   CHAIN           1..757
FT                   /note="Mitochondrial division protein 1"
FT                   /id="PRO_0000410335"
FT   REPEAT          353..394
FT                   /note="WD 1"
FT   REPEAT          396..432
FT                   /note="WD 2"
FT   REPEAT          491..528
FT                   /note="WD 3"
FT   REPEAT          602..645
FT                   /note="WD 4"
FT   REPEAT          648..685
FT                   /note="WD 5"
FT   REPEAT          687..724
FT                   /note="WD 6"
FT   REPEAT          728..757
FT                   /note="WD 7"
FT   REGION          69..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          454..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          225..300
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        550..564
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  82615 MW;  CD0CA06DAE569597 CRC64;
     MANHHDHDKP LRSALDPISS PYFSSLNGTL SIAKEVLIGP FQGDHRRSES ARILSDLAPS
     LMQPRFLNAA SSSQQSLSKS SHPGAPYPLL RLPTNLPFNK SSRPTASSLA ILEAVDNLAS
     LSLGDVSHPQ NGQNSPSLIR GFKATIPSSE LAKQRRRMVR GGIVDEDLGG KIGLKKLGDR
     ARGLLTEKGE DEEDGELGVG RHAVKKRRKK RESRRFTEGR HLEGKLRLED LAKQADEIGQ
     DKENLHVRQS LIQSEIAEVG AKIDALEDIR RHLEASLLHL QEEDLELDDE LEGVQELMAS
     PAIKAAAGAK SLPLSSSGAG ISNKSSRRRK GPAFLPSEHD ELPSGVAFMT LNGHTAPITA
     LDFDEPYGML VTAGQDDVVK VWDLCDGEEI GQLRGHRGTV KALQVEDTLC LTGGADGNVR
     LWDLRMVEDY EERLHTQLAE LARQDPLERI AEQRAHEEDG EHAEQDDELP DGTLQDPQPG
     DGSPCVRTLE GHSKSVTSLY YEDGCLVTGS SDKTIRQWDV ATGQCVLTMD ILWAISNPPP
     PPSSVPPQRP PRLSHRSSTS FGSNTYEDIL PSPGASLVGM SGAALLGAAT GQNFAVPTPP
     YADGTWEMYQ DFVGGVQFWG YALASGSGDG GVRMWDMRTG QAHRTLIGHT APVTCLQFDE
     QYIVTGSLDR TVRIWDLRMG SVSEVHKYEY PVTALQFDSR KVVACTGENG VEVYNRTTHA
     HSRLVVNGHT KPAEKMRFID KYLVSGGRDG CAKVWAM