ID   MDV1_EMENI              Reviewed;         654 AA.
AC   Q5AXW3; C8V2P4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Mitochondrial division protein 1;
GN   Name=mdv1; ORFNames=AN6867;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC       required to form mitochondrial fission complexes. Formation of these
CC       complexes is required to promote constriction and fission of the
CC       mitochondrial compartment at a late step in mitochondrial division (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA58266.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AACD01000113; EAA58266.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001301; CBF71624.1; -; Genomic_DNA.
DR   RefSeq; XP_664471.1; XM_659379.1.
DR   AlphaFoldDB; Q5AXW3; -.
DR   SMR; Q5AXW3; -.
DR   STRING; 162425.CADANIAP00007667; -.
DR   EnsemblFungi; CBF71624; CBF71624; ANIA_06867.
DR   EnsemblFungi; EAA58266; EAA58266; AN6867.2.
DR   GeneID; 2870567; -.
DR   KEGG; ani:AN6867.2; -.
DR   VEuPathDB; FungiDB:AN6867; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   HOGENOM; CLU_012350_1_1_1; -.
DR   InParanoid; Q5AXW3; -.
DR   OMA; IVGVWTC; -.
DR   OrthoDB; 927943at2759; -.
DR   Proteomes; UP000000560; Chromosome I.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central.
DR   GO; GO:0016559; P:peroxisome fission; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..654
FT                   /note="Mitochondrial division protein 1"
FT                   /id="PRO_0000330105"
FT   REPEAT          323..364
FT                   /note="WD 1"
FT   REPEAT          365..402
FT                   /note="WD 2"
FT   REPEAT          433..472
FT                   /note="WD 3"
FT   REPEAT          478..535
FT                   /note="WD 4"
FT   REPEAT          538..575
FT                   /note="WD 5"
FT   REPEAT          577..614
FT                   /note="WD 6"
FT   REPEAT          623..654
FT                   /note="WD 7"
FT   REGION          135..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          209..247
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        151..165
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   654 AA;  72066 MW;  9DC5456C81F22914 CRC64;
     MDKHRRDDSP SGLSDIVERD GLLGTGITSR HIEAFGRKVT STAGHLMGPS GDPSTSTHYQ
     NAMVDIHREL RRPSTQRKVF ALAQTTPTDL VRSKLSTSEI QSRAISSLPD ELLLNIPDDT
     SSYSLFEGFQ ATQNDHEYRK AHRRGRSKGK KLLKDKDGEQ ADPPSTLTEL KKERDLLSRR
     MELMGVRKNM CSSEIVDIDN KIANFHRMRQ IVLDRLAGLE MEEAELEHEV NEIDNKLDDM
     AEEEAAQAAQ AAAAAAAATT AGSETHEEPA SEDPAMDASF MSESIYQKLP SPRSLKHRSI
     RKRSMPVLHE HFAPGSEIKE FQAHTDVVTA LDLDYPFGTM ITAALDDTVR VWDLNIGRCT
     GFLEGHNASV RCLQIEDNVV ATGSMDATVK LWDLSRARTT HRDNRVNKDE DDDAVSVAYS
     TSLEDCHVYS LDAHVGEVTA LHFKGNTLVS GSADKTLRHW DLVKGRCVQT LDVLWAAAQA
     SSLGNESQWR PSGRLPDASA DFVGAVQCFD AALACGTADG MVRLWDLRSG QVHRSLVGHT
     GPVSCLQFDD VHLVTGSLDR SIRIWDLRMG SIYDAYGYDK PVTSMMFDTK RIVAAAGENV
     VKVYDKADGH HWDCGAGVGA DETGPDPAIV ERVRLKDGFL IEGRRDGIVA AWTC