ID   MDV1_NEOFI              Reviewed;         658 AA.
AC   A1DDL6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Mitochondrial division protein 1;
GN   Name=mdv1; ORFNames=NFIA_073890;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC       required to form mitochondrial fission complexes. Formation of these
CC       complexes is required to promote constriction and fission of the
CC       mitochondrial compartment at a late step in mitochondrial division (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR   EMBL; DS027696; EAW17473.1; -; Genomic_DNA.
DR   RefSeq; XP_001259370.1; XM_001259369.1.
DR   AlphaFoldDB; A1DDL6; -.
DR   SMR; A1DDL6; -.
DR   STRING; 36630.CADNFIAP00008053; -.
DR   EnsemblFungi; EAW17473; EAW17473; NFIA_073890.
DR   GeneID; 4586026; -.
DR   KEGG; nfi:NFIA_073890; -.
DR   VEuPathDB; FungiDB:NFIA_073890; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   HOGENOM; CLU_012350_1_1_1; -.
DR   OMA; IVGVWTC; -.
DR   OrthoDB; 927943at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..658
FT                   /note="Mitochondrial division protein 1"
FT                   /id="PRO_0000330108"
FT   REPEAT          319..360
FT                   /note="WD 1"
FT   REPEAT          361..398
FT                   /note="WD 2"
FT   REPEAT          437..476
FT                   /note="WD 3"
FT   REPEAT          482..539
FT                   /note="WD 4"
FT   REPEAT          542..581
FT                   /note="WD 5"
FT   REPEAT          583..618
FT                   /note="WD 6"
FT   REPEAT          629..658
FT                   /note="WD 7"
FT   REGION          138..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          209..246
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   658 AA;  72471 MW;  0A0FB440558A077B CRC64;
     MATQRRDESP SGLSDIVEPD GLLGIGLTSR HIEAFGRKVT STAGHLMGPI TDSSNGGHYH
     TAMADIHREL RRPTTQRKVF SLTQTTPTDL VRSKLSTSEI QSRALSSLPD ELLANIPEDS
     SSYSLFEGFK ATQDDHEFRK AHRRRSSKGK KLLKDGEAAG ALPSAPTDLK KERDLLSRRL
     DLMGVRKNMC SSEIHEIDNK IANLHNMRKI VLDRLAGLEM EEAELEHQLT EIDNKLEDIQ
     EEAPKTPVTA ATPKSSAVND DSFVSEDAAM DASFMSESIY QKLPSHSPRS LKQRSIRKRS
     MPILHEHFAP GSQIKEMQAH TDMVTAIDFD YPFGTMVSAA LDDTVRVWDL NIGRCTGFLE
     GHNASVRCLQ VEDNIVATGS MDASVKLWDL SRARTVTRDN RLNKHEEGEG EDDNASDAFS
     LFSATTLEDC YVFSLDAHVD EVTALHFRGN TLISGSADKT LRQWDLVKGR CVQTLDVLWA
     AAQASTLAAD TQWRPSGRLP DASADFVGAL QCFDAALACG TADGMVRLWD LRSGQVHRSL
     VGHTGPITCL QFDEVHLVTG SQDRSIRIWD LRMGSIFDAY AYDKPITSMM FDTKRIVAAA
     GENVVKVYDK ADGHHWDCGA GVGADESGPA PATVERVRLK DGYLLEGRKD GTVAAWTC