ID   MDV1_NEUCR              Reviewed;         653 AA.
AC   Q7S8R5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Mitochondrial division protein 1;
GN   Name=mdv1; ORFNames=NCU07724;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC       required to form mitochondrial fission complexes. Formation of these
CC       complexes is required to promote constriction and fission of the
CC       mitochondrial compartment at a late step in mitochondrial division (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR   EMBL; CM002239; EAA32738.2; -; Genomic_DNA.
DR   RefSeq; XP_961974.2; XM_956881.2.
DR   AlphaFoldDB; Q7S8R5; -.
DR   SMR; Q7S8R5; -.
DR   STRING; 5141.EFNCRP00000008036; -.
DR   EnsemblFungi; EAA32738; EAA32738; NCU07724.
DR   GeneID; 3878122; -.
DR   KEGG; ncr:NCU07724; -.
DR   VEuPathDB; FungiDB:NCU07724; -.
DR   HOGENOM; CLU_012350_1_1_1; -.
DR   InParanoid; Q7S8R5; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central.
DR   GO; GO:0016559; P:peroxisome fission; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..653
FT                   /note="Mitochondrial division protein 1"
FT                   /id="PRO_0000330109"
FT   REPEAT          313..354
FT                   /note="WD 1"
FT   REPEAT          355..392
FT                   /note="WD 2"
FT   REPEAT          431..470
FT                   /note="WD 3"
FT   REPEAT          491..534
FT                   /note="WD 4"
FT   REPEAT          537..576
FT                   /note="WD 5"
FT   REPEAT          578..613
FT                   /note="WD 6"
FT   REPEAT          618..653
FT                   /note="WD 7"
FT   REGION          246..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          207..251
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   653 AA;  72365 MW;  902D00979A8DAC5D CRC64;
     MANSDQNRDV FPDDVSIDDD TSVISTRGLE AFGRKVTTTA SHLIGPITDP TSHPHYQTAM
     TEIHKQLQKP TLQRGVFAIA RTTPTDLVRS KLSSKEIQSR ALAYVPDELL RNIPASSNSY
     SLFQGFQASF PDFTDDGKKH KRRVSRGRKM LDESPVQPGS PHAVQRLKKD KASMMHQLEM
     LGVRKNMASS EIREIDNKIA NLHGMRKIIL DRLANLEKEE AVLEHDIMDV ESRLDEAQEL
     ADEAESLAMA TPNKSEEDLS RTEEGFMSQS IYEKLPAANT PPGKKKPRNH RKKTLPILHE
     HFEPGTMIRS MRAHQDNITA LDFDAPFGLM VSAAMDDSVR VWDLNAGRCI GTLEGHTASV
     RTLQIEDNFL ATGSMDATIK LWDLSKAHYD PQGSQEVDEE DEDLAFVNPN DHAVDPPAGS
     MADCPLFTLE AHLDEITALH FRGDVLVSGS ADKTLRQWDL TKGRCVQTLD VMWAAAQATA
     MGSSDGPWRQ TSRSADGSAD FVGALQVFES ALACGTADGM VRLWDLRSGQ VHRSLVGHTG
     PVTCLQFDDV HLVTGSLDRS IRIWDLRTGS IFDAYAYDHP ITSMMFDTRR IVCAAGEDVV
     KVYDKVEGRH WDCGAGITEA EKAKSPAIVE RVRIRDGYMV EGRQDGVVGV WTC