MDV1_SCHPO
ID MDV1_SCHPO Reviewed; 651 AA.
AC Q9P7I3; Q9URZ9;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Mitochondrial division protein 1;
GN Name=mdv1; ORFNames=SPAC25D11.01, SPAC664.15, SPACUNK12.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC required to form mitochondrial fission complexes. Formation of these
CC complexes is required to promote constriction and fission of the
CC mitochondrial compartment at a late step in mitochondrial division (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB65816.1; -; Genomic_DNA.
DR PIR; T50245; T50245.
DR PIR; T50289; T50289.
DR RefSeq; XP_001713057.1; XM_001713005.2.
DR AlphaFoldDB; Q9P7I3; -.
DR SMR; Q9P7I3; -.
DR BioGRID; 280602; 121.
DR IntAct; Q9P7I3; 5.
DR STRING; 4896.SPAC664.15.1; -.
DR iPTMnet; Q9P7I3; -.
DR MaxQB; Q9P7I3; -.
DR PaxDb; Q9P7I3; -.
DR PRIDE; Q9P7I3; -.
DR EnsemblFungi; SPAC664.15.1; SPAC664.15.1:pep; SPAC664.15.
DR PomBase; SPAC664.15; -.
DR VEuPathDB; FungiDB:SPAC664.15; -.
DR eggNOG; KOG4155; Eukaryota.
DR HOGENOM; CLU_012350_1_1_1; -.
DR InParanoid; Q9P7I3; -.
DR OMA; IVGVWTC; -.
DR PhylomeDB; Q9P7I3; -.
DR PRO; PR:Q9P7I3; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0030015; C:CCR4-NOT core complex; NAS:PomBase.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISO:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0051020; F:GTPase binding; NAS:PomBase.
DR GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IC:PomBase.
DR GO; GO:0016559; P:peroxisome fission; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..651
FT /note="Mitochondrial division protein 1"
FT /id="PRO_0000051490"
FT REPEAT 330..369
FT /note="WD 1"
FT REPEAT 372..409
FT /note="WD 2"
FT REPEAT 433..473
FT /note="WD 3"
FT REPEAT 492..531
FT /note="WD 4"
FT REPEAT 534..573
FT /note="WD 5"
FT REPEAT 575..610
FT /note="WD 6"
FT REPEAT 620..650
FT /note="WD 7"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 195..229
FT /evidence="ECO:0000255"
SQ SEQUENCE 651 AA; 72373 MW; 4F59D1104A650DBA CRC64;
MTDNNSKSKD SSQKIPNDSL TPTISKGLRK DVFYWTKAIA YTTWNFFDSS PVTPQRNPIS
LFVRGLSHPF LRHRLSKSQF NEWFLSHNGV DPVQAQTLPD PLLFDIPDHQ ETSYSLLEGY
SVTAHDHSDT SPLPITSSNQ KEGKKNVSSI DVSMVSDSSE FKPDSLQHEK LVKKCNQLRL
QKLINSSELA QIDLELSKLY SRRRQVLERL SKIEEQNLKY TSKLASVEKL MLDSDAQDLY
SSYSHDLIPS QIEAGKNGAN PDVFDDTHDK YTDNLSARAI SPRAPRPSTA SEVVSDYFEQ
NSAFSKAPEN TESSVNQNYI VGNLVKQFQA HSEYITSLDF SHPFGTLATA STDKTVKVWD
MAGVVYLGSL KGHSDYVSCL AIQDSFIATG SMDTTVRLWN LDNDVLHKDN PVEESLNSPP
DQPVDNATNV LTSHTAPVTA LALSSDDVLI TGADDKTVRQ WDIVTGRCIQ TLDFVWAETH
DTSTSQILVS DTYKQEPFIR ALDCLDAAVA SGTVDGLIRI WDLRIGLPVR SFIGHTAPIS
SLQFDSNHLY SGSYDNSVRI WDLRSGSPIN IIPMEKKVNS LRLYQGRLAV ASDEPNVRIF
DTVSNRNWIC SIPSHSDSIA AEPNSVPTSV QYKDRFLVDG KSDGSVSVFS A
