ID   MDV1_YARLI              Reviewed;         565 AA.
AC   Q6CB13;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Mitochondrial division protein 1;
GN   Name=MDV1; OrderedLocusNames=YALI0C22704g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in mitochondrial fission. Acts as an adapter protein
CC       required to form mitochondrial fission complexes. Formation of these
CC       complexes is required to promote constriction and fission of the
CC       mitochondrial compartment at a late step in mitochondrial division (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR   EMBL; CR382129; CAG82469.1; -; Genomic_DNA.
DR   RefSeq; XP_502149.1; XM_502149.1.
DR   AlphaFoldDB; Q6CB13; -.
DR   SMR; Q6CB13; -.
DR   STRING; 4952.CAG82469; -.
DR   EnsemblFungi; CAG82469; CAG82469; YALI0_C22704g.
DR   GeneID; 2909670; -.
DR   KEGG; yli:YALI0C22704g; -.
DR   VEuPathDB; FungiDB:YALI0_C22704g; -.
DR   HOGENOM; CLU_012350_1_1_1; -.
DR   InParanoid; Q6CB13; -.
DR   OMA; IVGVWTC; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central.
DR   GO; GO:0016559; P:peroxisome fission; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..565
FT                   /note="Mitochondrial division protein 1"
FT                   /id="PRO_0000330114"
FT   REPEAT          256..295
FT                   /note="WD 1"
FT   REPEAT          298..335
FT                   /note="WD 2"
FT   REPEAT          351..390
FT                   /note="WD 3"
FT   REPEAT          401..452
FT                   /note="WD 4"
FT   REPEAT          453..492
FT                   /note="WD 5"
FT   REPEAT          494..529
FT                   /note="WD 6"
FT   REPEAT          534..565
FT                   /note="WD 7"
FT   COILED          119..224
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   565 AA;  62531 MW;  C9DED148DEF8AA47 CRC64;
     MSDVTHFSKV VAATASTLVS GDLSQSHVMR DISRPAFQKR IFSFSKRPSE LVRITSSSKD
     VLLPDEMLVD IPSNENQFSL FQGFQATLPE HSVGSQLLLG DGSKVGEKSA REQLVEGKKS
     LSHKLDLLEV RKALAANEIT EIDARVAHLQ SMRQIVFDRV ASLEQQEFQL ESEVLRIDAE
     LEQMEEEKEE VIQRHDYETR TPEELEDDVV DLKSVSEKLQ SASQKTLPRR NLSRRKTQPT
     LQQYYEPGNK IRQIKAHSDS VTCLDFDIPF GTMVSAGMDL GLKVWDLSRG DLVTDLKGHN
     ASVTCLQVDN NVLATGSADA TIRVWNLDQV VSNPDAQDEG DDAYTIHVLD SHVGEISAIH
     FSDHTLVSGS ADKTIRQWDL NTGRCVQTLD VIWANSAQNA LYSNDRLRTG FDANAPFIGA
     VQCRDAALAT GTADGIVRLW DLRSGQVQRT LQGHTAAVTC LQFDDVHLAT GSRDRSVRIW
     DLRMGNIFDA FAYDSPITSL DFDNRRIAST NGENTVKIYD RAAEKHWSLG RGEGDPEAPE
     STVVKTKEGY LVEGGGDGVV GVWAC