ME15P_HUMAN
ID ME15P_HUMAN Reviewed; 234 AA.
AC P0C7V9;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Putative methyltransferase-like protein 15P1;
DE EC=2.1.1.-;
DE AltName: Full=Methyltransferase 5 domain-containing protein 2;
DE AltName: Full=Methyltransferase-like protein 15 pseudogene 1;
GN Name=METTL15P1; Synonyms=METT5D2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 152-216.
RX PubMed=10737800; DOI=10.1073/pnas.97.7.3491;
RA Dias Neto E., Correa R.G., Verjovski-Almeida S., Briones M.R.S.,
RA Nagai M.A., da Silva W. Jr., Zago M.A., Bordin S., Costa F.F.,
RA Goldman G.H., Carvalho A.F., Matsukuma A., Baia G.S., Simpson D.H.,
RA Brunstein A., de Oliveira P.S.L., Bucher P., Jongeneel C.V., O'Hare M.J.,
RA Soares F., Brentani R.R., Reis L.F.L., de Souza S.J., Simpson A.J.G.;
RT "Shotgun sequencing of the human transcriptome with ORF expressed sequence
RT tags.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:3491-3496(2000).
CC -!- FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RsmH family.
CC {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC106708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BF352768; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0C7V9; -.
DR SMR; P0C7V9; -.
DR iPTMnet; P0C7V9; -.
DR PhosphoSitePlus; P0C7V9; -.
DR BioMuta; HGNC:31926; -.
DR jPOST; P0C7V9; -.
DR MassIVE; P0C7V9; -.
DR MaxQB; P0C7V9; -.
DR PeptideAtlas; P0C7V9; -.
DR PRIDE; P0C7V9; -.
DR ProteomicsDB; 52379; -.
DR GeneCards; METTL15P1; -.
DR HGNC; HGNC:31926; METTL15P1.
DR neXtProt; NX_P0C7V9; -.
DR InParanoid; P0C7V9; -.
DR PhylomeDB; P0C7V9; -.
DR Pharos; P0C7V9; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0C7V9; protein.
DR GO; GO:0071424; F:rRNA (cytosine-N4-)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0070475; P:rRNA base methylation; IBA:GO_Central.
DR Gene3D; 1.10.150.170; -; 1.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR002903; RsmH.
DR InterPro; IPR023397; SAM-dep_MeTrfase_MraW_recog.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11265; PTHR11265; 1.
DR Pfam; PF01795; Methyltransf_5; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 5: Uncertain;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..234
FT /note="Putative methyltransferase-like protein 15P1"
FT /id="PRO_0000344465"
FT BINDING 100..102
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 119
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 146
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 169
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 176
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
SQ SEQUENCE 234 AA; 26716 MW; 018376A721D91A5F CRC64;
MLRYPYFCRM YKECLSCWLE SGIPNLGVWP KRIHTTAEKY REYEAREQTD QTQVQELHRS
QDRDFETMAK LHIPVMVDEV VHCLSPQKGQ IFLDMTFGSG GHTKAILQKE SDIVLYALDR
DPTAYALAEH LSELYPKQIR AMLGQFSQAE ALLMKAGVQP GTFDGVLMDL GCSSMQLDTP
ERGSSLRKDG PLDIRMDGGR NISSLCYLYT ERLTTAIYLY CHQDFPGSSH ICEQ
