ID   ME178_GIBF5             Reviewed;         351 AA.
AC   S0EG57;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Methyltransferase FFUJ_09178 {ECO:0000303|PubMed:28295904};
DE            EC=2.1.1.- {ECO:0000305|PubMed:28295904};
DE   AltName: Full=DMATS1 biosynthesis cluster protein FFUJ_09178 {ECO:0000303|PubMed:28295904};
GN   ORFNames=FFUJ_09178;
OS   Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS   and foot rot disease fungus) (Fusarium fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=1279085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA   Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA   Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA   Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA   Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA   Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA   Tudzynski B.;
RT   "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT   Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT   novel metabolites.";
RL   PLoS Pathog. 9:E1003475-E1003475(2013).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28295904; DOI=10.1002/cbic.201600691;
RA   Arndt B., Janevska S., Schmid R., Huebner F., Tudzynski B., Humpf H.U.;
RT   "A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi.";
RL   ChemBioChem 18:899-904(2017).
CC   -!- FUNCTION: Methyltransferase; part of the DMATS1 gene cluster that
CC       mediates the biosynthesis of a reversely N-prenylated monomeric L-
CC       tryptophan (r-N-DMAT) (PubMed:28295904). Seems not to contribute to the
CC       final DMATS1 product (PubMed:28295904). {ECO:0000269|PubMed:28295904}.
CC   -!- INDUCTION: Expression is negaticely regulated by the global nitrogen
CC       regulator areA. {ECO:0000269|PubMed:28295904}.
CC   -!- DISRUPTION PHENOTYPE: Does not alter the amount of produced r-N-DMAT.
CC       {ECO:0000269|PubMed:28295904}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. LaeA
CC       methyltransferase family. {ECO:0000305}.
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DR   EMBL; HF679031; CCT73986.1; -; Genomic_DNA.
DR   AlphaFoldDB; S0EG57; -.
DR   SMR; S0EG57; -.
DR   EnsemblFungi; CCT73986; CCT73986; FFUJ_09178.
DR   VEuPathDB; FungiDB:FFUJ_09178; -.
DR   HOGENOM; CLU_010595_0_0_1; -.
DR   Proteomes; UP000016800; Chromosome 9.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..351
FT                   /note="Methyltransferase FFUJ_09178"
FT                   /id="PRO_0000452658"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..47
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  39330 MW;  F0BFA40466B4E43A CRC64;
     MSQKSPKSGS PRSPRSPQSQ GPVATAAQAL EVDDLPEGEE DDPGLGEDFE SSTASITSSI
     LHYRTINGRT YHSERGNAAY WGSNDERQSE AMDIAHHMFT LSQSGELHLA PLSDNIQKVL
     DVGCGTGIWA IDFADKYPGC EVIGTDISPI QPSWVPPNVK FEIEDFNQDW TFPPESFDYV
     HLRYLVGCVP NWDNLFEQAF KVLKPGGWVE SFEASAIIES DDDSVKPDSA LAQWGPIFIK
     ASKTIGNTFT VVGDNLQRPG IEKAGFIDVE QWDSKLPLNP FPKDPKLKEM GQFGELFSTR
     DTEGLVLFVA NTLGWTPEEV HVYIAKFRRE IRDRRNHPYI RLRTVWARKP E