ID   MEA1_BOVIN              Reviewed;         174 AA.
AC   Q29407; Q3T097;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Male-enhanced antigen 1;
DE            Short=MEA-1;
GN   Name=MEA1; Synonyms=MEA;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=8268232; DOI=10.1016/0167-4781(93)90019-a;
RA   Kondo M., Sato S., Sutou S.;
RT   "Cloning and sequence analysis of cDNA encoding the bovine testis-derived
RT   male-enhanced antigen (Mea).";
RL   Biochim. Biophys. Acta 1216:483-486(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8907304; DOI=10.3109/10425179609010194;
RA   Kondo M., Terouchi S., Tsukasa N., Sato S., Ishida N., Sutou S.;
RT   "Genomic sequence analysis of the bovine male-enhanced antigen-1 (Mea-1)
RT   and differential localization of its transcripts and products during
RT   spermatogenesis.";
RL   DNA Seq. 6:75-85(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important role in spermatogenesis and/or testis
CC       development.
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis. Transcripts can be
CC       found in primary and secondary spermatocytes, and spermatids, but the
CC       protein itself is only detected in spermatids. No expression in Leydig
CC       cells, spermatogonia, or sperm. Very weak expression in the heart,
CC       kidney, spleen, thymus and ovary.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the stages from 8-cell embryos to
CC       hatched blastocysts.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-11 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; D17340; BAA04158.1; -; mRNA.
DR   EMBL; D30811; BAA06488.1; -; Genomic_DNA.
DR   EMBL; BC102492; AAI02493.1; -; mRNA.
DR   PIR; S39790; S39790.
DR   RefSeq; NP_777073.1; NM_174648.2.
DR   RefSeq; XP_005223438.1; XM_005223381.3.
DR   RefSeq; XP_010816469.1; XM_010818167.2.
DR   AlphaFoldDB; Q29407; -.
DR   STRING; 9913.ENSBTAP00000014178; -.
DR   PaxDb; Q29407; -.
DR   PRIDE; Q29407; -.
DR   Ensembl; ENSBTAT00000014178; ENSBTAP00000014178; ENSBTAG00000005536.
DR   Ensembl; ENSBTAT00000073321; ENSBTAP00000072475; ENSBTAG00000005536.
DR   Ensembl; ENSBTAT00000078720; ENSBTAP00000064096; ENSBTAG00000005536.
DR   GeneID; 282462; -.
DR   KEGG; bta:282462; -.
DR   CTD; 4201; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005536; -.
DR   eggNOG; ENOG502S34Y; Eukaryota.
DR   GeneTree; ENSGT00390000016927; -.
DR   HOGENOM; CLU_096511_0_0_1; -.
DR   InParanoid; Q29407; -.
DR   OMA; MGPERIC; -.
DR   OrthoDB; 1638941at2759; -.
DR   TreeFam; TF332365; -.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000005536; Expressed in spermatocyte and 106 other tissues.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR009685; MEA1.
DR   PANTHER; PTHR17005; PTHR17005; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Phosphoprotein; Reference proteome;
KW   Spermatogenesis.
FT   CHAIN           1..174
FT                   /note="Male-enhanced antigen 1"
FT                   /id="PRO_0000096340"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         103
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16626"
SQ   SEQUENCE   174 AA;  18751 MW;  E0E7CE99C0CB3530 CRC64;
     MATVVLGGDT MGPERIFPNQ TEELGPHQGP TEGTGDWSSE EPEEEQEETG AGPAGYSYQP
     LNQDPEQEEV ELAPVGDGED VVADIQDRIQ ALGLHLPDPP VESEDEDEQG ATALNNHSSI
     PMDPEHVELV KRTMAGISLP APGVPAWARE LSDAQWEDVV QKALQARQAA PAWK