MEA1_HUMAN
ID MEA1_HUMAN Reviewed; 185 AA.
AC Q16626; Q5TC36; Q9BV01;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Male-enhanced antigen 1;
DE Short=MEA-1;
GN Name=MEA1; Synonyms=MEA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=2813404; DOI=10.1073/pnas.86.21.8462;
RA Lau Y.-F.C., Chan K., Sparkes R.S.;
RT "Male-enhanced antigen gene is phylogenetically conserved and expressed at
RT late stages of spermatogenesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:8462-8466(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: May play an important role in spermatogenesis and/or testis
CC development.
CC -!- INTERACTION:
CC Q16626; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-744921, EBI-541426;
CC Q16626; P63010: AP2B1; NbExp=2; IntAct=EBI-744921, EBI-432924;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis.
CC -!- CAUTION: Was originally thought to be the H-Y antigen. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1, Met-14 or Met-24 is the
CC initiator. {ECO:0000305}.
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DR EMBL; M27937; AAA36208.1; -; mRNA.
DR EMBL; L10400; AAA36209.1; -; mRNA.
DR EMBL; BT009831; AAP88833.1; -; mRNA.
DR EMBL; AL136304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001754; AAH01754.1; -; mRNA.
DR CCDS; CCDS4879.1; -.
DR PIR; A34421; A34421.
DR RefSeq; NP_055438.1; NM_014623.3.
DR AlphaFoldDB; Q16626; -.
DR BioGRID; 110365; 21.
DR IntAct; Q16626; 6.
DR STRING; 9606.ENSP00000244711; -.
DR iPTMnet; Q16626; -.
DR PhosphoSitePlus; Q16626; -.
DR BioMuta; MEA1; -.
DR DMDM; 239938667; -.
DR EPD; Q16626; -.
DR jPOST; Q16626; -.
DR MassIVE; Q16626; -.
DR MaxQB; Q16626; -.
DR PaxDb; Q16626; -.
DR PeptideAtlas; Q16626; -.
DR PRIDE; Q16626; -.
DR ProteomicsDB; 60973; -.
DR Antibodypedia; 16204; 93 antibodies from 22 providers.
DR DNASU; 4201; -.
DR Ensembl; ENST00000244711.4; ENSP00000244711.3; ENSG00000124733.5.
DR GeneID; 4201; -.
DR KEGG; hsa:4201; -.
DR MANE-Select; ENST00000244711.4; ENSP00000244711.3; NM_014623.4; NP_055438.1.
DR UCSC; uc003otk.4; human.
DR CTD; 4201; -.
DR DisGeNET; 4201; -.
DR GeneCards; MEA1; -.
DR HGNC; HGNC:6986; MEA1.
DR HPA; ENSG00000124733; Low tissue specificity.
DR MalaCards; MEA1; -.
DR MIM; 143170; gene.
DR neXtProt; NX_Q16626; -.
DR OpenTargets; ENSG00000124733; -.
DR PharmGKB; PA30726; -.
DR VEuPathDB; HostDB:ENSG00000124733; -.
DR eggNOG; ENOG502S34Y; Eukaryota.
DR GeneTree; ENSGT00390000016927; -.
DR HOGENOM; CLU_096511_0_0_1; -.
DR InParanoid; Q16626; -.
DR OMA; MGPERIC; -.
DR OrthoDB; 1638941at2759; -.
DR PhylomeDB; Q16626; -.
DR TreeFam; TF332365; -.
DR PathwayCommons; Q16626; -.
DR SignaLink; Q16626; -.
DR BioGRID-ORCS; 4201; 12 hits in 1075 CRISPR screens.
DR ChiTaRS; MEA1; human.
DR GenomeRNAi; 4201; -.
DR Pharos; Q16626; Tbio.
DR PRO; PR:Q16626; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q16626; protein.
DR Bgee; ENSG00000124733; Expressed in left testis and 214 other tissues.
DR ExpressionAtlas; Q16626; baseline and differential.
DR Genevisible; Q16626; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008584; P:male gonad development; TAS:ProtInc.
DR GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR InterPro; IPR009685; MEA1.
DR PANTHER; PTHR17005; PTHR17005; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Phosphoprotein; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..185
FT /note="Male-enhanced antigen 1"
FT /id="PRO_0000096341"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 114
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976"
FT VARIANT 183
FT /note="A -> D (in dbSNP:rs11751058)"
FT /id="VAR_058297"
SQ SEQUENCE 185 AA; 19905 MW; F50E6892FBA7435C CRC64;
MGPERHLSGA PARMATVVLG GDTMGPERIF PNQTEELGHQ GPSEGTGDWS SEEPEEEQEE
TGSGPAGYSY QPLNQDPEQE EVELAPVGDG DVVADIQDRI QALGLHLPDP PLESEDEDEE
GATALNNHSS IPMDPEHVEL VKRTMAGVSL PAPGVPAWAR EISDAQWEDV VQKALQARQA
SPAWK
