MEA1_MOUSE
ID MEA1_MOUSE Reviewed; 174 AA.
AC Q64327; Q793G4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Male-enhanced antigen 1;
DE Short=MEA-1;
GN Name=Mea1; Synonyms=Mea;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2813404; DOI=10.1073/pnas.86.21.8462;
RA Lau Y.-F.C., Chan K., Sparkes R.S.;
RT "Male-enhanced antigen gene is phylogenetically conserved and expressed at
RT late stages of spermatogenesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:8462-8466(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=8268232; DOI=10.1016/0167-4781(93)90019-a;
RA Kondo M., Sato S., Sutou S.;
RT "Cloning and sequence analysis of cDNA encoding the bovine testis-derived
RT male-enhanced antigen (Mea).";
RL Biochim. Biophys. Acta 1216:483-486(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/SvJ;
RX PubMed=12444059; DOI=10.1095/biolreprod.101.002550;
RA Ohinata Y., Sutou S., Kondo M., Takahashi T., Mitsui Y.;
RT "Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed
RT in late spermatogenesis.";
RL Biol. Reprod. 67:1824-1831(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Liver, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play an important role in spermatogenesis and/or testis
CC development.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Transcripts can be
CC found in primary and secondary spermatocytes, and spermatids, but the
CC protein itself is only detected in spermatids. No expression in Leydig
CC cells, spermatogonia, or sperm. Very weak expression in the heart,
CC kidney, spleen, thymus and ovary. {ECO:0000269|PubMed:12444059}.
CC -!- DEVELOPMENTAL STAGE: Expressed as early as day 6 postpartum (dpp), with
CC higher expression in the adult testis.
CC -!- CAUTION: Was originally thought to be the H-Y antigen. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-11 is the initiator.
CC {ECO:0000305}.
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DR EMBL; M27938; AAA39519.1; -; mRNA.
DR EMBL; L10401; AAA39520.1; -; mRNA.
DR EMBL; D17341; BAA04159.1; -; mRNA.
DR EMBL; AB074009; BAB91440.1; -; Genomic_DNA.
DR EMBL; AK005369; BAB23978.1; -; mRNA.
DR EMBL; AK008194; BAB25525.1; -; mRNA.
DR EMBL; AK008305; BAB25590.1; -; mRNA.
DR EMBL; AK010863; BAB27231.1; -; mRNA.
DR EMBL; AK010904; BAB27257.1; -; mRNA.
DR EMBL; AK010962; BAB27294.1; -; mRNA.
DR EMBL; AK012617; BAB28358.1; -; mRNA.
DR EMBL; CH466559; EDL23523.1; -; Genomic_DNA.
DR EMBL; CH466559; EDL23524.1; -; Genomic_DNA.
DR EMBL; CH466559; EDL23525.1; -; Genomic_DNA.
DR EMBL; CH466559; EDL23526.1; -; Genomic_DNA.
DR EMBL; CH466559; EDL23527.1; -; Genomic_DNA.
DR EMBL; CH466559; EDL23528.1; -; Genomic_DNA.
DR EMBL; CH466559; EDL23529.1; -; Genomic_DNA.
DR EMBL; BC013344; AAH13344.1; -; mRNA.
DR CCDS; CCDS28835.1; -.
DR PIR; B34421; B34421.
DR RefSeq; NP_001264238.1; NM_001277309.1.
DR RefSeq; NP_001264239.1; NM_001277310.1.
DR RefSeq; NP_001264240.1; NM_001277311.1.
DR RefSeq; NP_001264241.1; NM_001277312.1.
DR RefSeq; NP_034917.1; NM_010787.2.
DR RefSeq; XP_006523811.1; XM_006523748.3.
DR RefSeq; XP_006523812.1; XM_006523749.3.
DR RefSeq; XP_006523813.1; XM_006523750.3.
DR AlphaFoldDB; Q64327; -.
DR BioGRID; 201379; 6.
DR STRING; 10090.ENSMUSP00000002845; -.
DR iPTMnet; Q64327; -.
DR PhosphoSitePlus; Q64327; -.
DR EPD; Q64327; -.
DR MaxQB; Q64327; -.
DR PaxDb; Q64327; -.
DR PeptideAtlas; Q64327; -.
DR PRIDE; Q64327; -.
DR ProteomicsDB; 295722; -.
DR Antibodypedia; 16204; 93 antibodies from 22 providers.
DR DNASU; 17256; -.
DR Ensembl; ENSMUST00000002845; ENSMUSP00000002845; ENSMUSG00000002768.
DR Ensembl; ENSMUST00000232732; ENSMUSP00000156392; ENSMUSG00000002768.
DR Ensembl; ENSMUST00000232762; ENSMUSP00000156895; ENSMUSG00000002768.
DR Ensembl; ENSMUST00000233430; ENSMUSP00000156593; ENSMUSG00000002768.
DR Ensembl; ENSMUST00000233491; ENSMUSP00000156439; ENSMUSG00000002768.
DR Ensembl; ENSMUST00000233612; ENSMUSP00000156967; ENSMUSG00000002768.
DR GeneID; 17256; -.
DR KEGG; mmu:17256; -.
DR UCSC; uc008cty.2; mouse.
DR CTD; 4201; -.
DR MGI; MGI:96957; Mea1.
DR VEuPathDB; HostDB:ENSMUSG00000002768; -.
DR eggNOG; ENOG502S34Y; Eukaryota.
DR GeneTree; ENSGT00390000016927; -.
DR HOGENOM; CLU_096511_0_0_1; -.
DR InParanoid; Q64327; -.
DR OMA; MGPERIC; -.
DR OrthoDB; 1638941at2759; -.
DR PhylomeDB; Q64327; -.
DR TreeFam; TF332365; -.
DR BioGRID-ORCS; 17256; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Mea1; mouse.
DR PRO; PR:Q64327; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q64327; protein.
DR Bgee; ENSMUSG00000002768; Expressed in seminiferous tubule of testis and 267 other tissues.
DR ExpressionAtlas; Q64327; baseline and differential.
DR Genevisible; Q64327; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR009685; MEA1.
DR PANTHER; PTHR17005; PTHR17005; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Phosphoprotein; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..174
FT /note="Male-enhanced antigen 1"
FT /id="PRO_0000096342"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 103
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 174 AA; 18584 MW; C3B16361635B176F CRC64;
MAAVVLGGDT MGPERIFPNQ TEDLGPHQGP TEGTGDWSSE EPEEEQEETG AGPAGYSYQP
LNQDPEQEEV ELAPVGEGED GAADIQDRIQ ALGLHLPDPP LESEDEDEEG AAALSSHSSI
PMDPEHVELV KRTMAGVSLP APGVPAWARE ISDAQWEDVV QKALQARQAS PAWK
