MEAK7_CHICK
ID MEAK7_CHICK Reviewed; 468 AA.
AC Q5ZJX5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=MTOR-associated protein MEAK7 {ECO:0000305};
DE Short=MEAK7 {ECO:0000305};
DE AltName: Full=TBC/LysM-associated domain-containing protein 1;
DE AltName: Full=TLD domain-containing protein 1;
GN Name=MEAK7; Synonyms=KIAA1609, TLDC1; ORFNames=RCJMB04_14k7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Activates an alternative mTOR signaling to regulate cell
CC proliferation and migration. {ECO:0000250|UniProtKB:Q6P9B6}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q6P9B6}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q6P9B6}. Lysosome
CC {ECO:0000250|UniProtKB:Q6P9B6}.
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DR EMBL; AJ720309; CAG31968.1; -; mRNA.
DR RefSeq; NP_001025746.1; NM_001030575.1.
DR AlphaFoldDB; Q5ZJX5; -.
DR SMR; Q5ZJX5; -.
DR STRING; 9031.ENSGALP00000028898; -.
DR PaxDb; Q5ZJX5; -.
DR GeneID; 415815; -.
DR KEGG; gga:415815; -.
DR CTD; 415815; -.
DR VEuPathDB; HostDB:geneid_415815; -.
DR eggNOG; KOG2557; Eukaryota.
DR InParanoid; Q5ZJX5; -.
DR OrthoDB; 585082at2759; -.
DR PhylomeDB; Q5ZJX5; -.
DR PRO; PR:Q5ZJX5; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0150032; P:positive regulation of protein localization to lysosome; ISS:UniProtKB.
DR GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0043200; P:response to amino acid; ISS:UniProtKB.
DR GO; GO:0032868; P:response to insulin; ISS:UniProtKB.
DR GO; GO:0031667; P:response to nutrient levels; ISS:UniProtKB.
DR GO; GO:0031929; P:TOR signaling; ISS:UniProtKB.
DR InterPro; IPR006571; TLDc_dom.
DR Pfam; PF07534; TLD; 1.
DR SMART; SM00584; TLDc; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lysosome; Membrane; Reference proteome.
FT CHAIN 1..468
FT /note="MTOR-associated protein MEAK7"
FT /id="PRO_0000313642"
FT DOMAIN 252..420
FT /note="TLDc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT REGION 445..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 52115 MW; 755ED70400F3F699 CRC64;
MGNAESNAYR NHLSRFLPEE QSDVDGLFDT LSGSSSSAAA KNGKAMKKTM TLEALKAYMR
EPLPEQMTVR LYNGMRSIDL TGKSSALSDH VAKEQFVIFM SNLLKGNADE KITIIMRMIS
TTEGPVKGKE IQEFTEDLIK SVVHVLSYRK ELKGWTLENT RDSAGGIKAL SSQLLSELKL
ADGTKAVSPQ LMEMSFDRSV IEDWVYRVPQ ISAFLSVVLR QGLHVLHSLP DQTKDIVNLV
PGCKGIKGRI VSLFDIPSII YINSHLPAEL QHKWRLLFSS KLHGESFSQL CAHIVNKGPC
VVILKDTDGF IFGGFASHSW EVKPQFQGDN RCFLFSVFPS LAVYTYTGYN DHYMYLNHGQ
QTMPNGLGMG GQHDYFGLWV DSDYGKGHSK AKPRCTTYNS PQLSAKENFT LDALEVWAVG
DMPESAETKG KKSILDVDPE AQALLEMTGK SRHSEGLREP IEDEDDDN
