ID   ARGR_STRCL              Reviewed;         178 AA.
AC   P95721; Q9LCS4;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Arginine repressor;
GN   Name=argR;
OS   Streptomyces clavuligerus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL
RC   3585 / VKM Ac-602;
RX   PubMed=9282734; DOI=10.1046/j.1365-2958.1997.4511815.x;
RA   Rodriguez-Garcia A., Ludovice M., Martin J.F., Liras P.;
RT   "Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence
RT   for a clear regulation of the arginine pathway.";
RL   Mol. Microbiol. 25:219-228(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL
RC   3585 / VKM Ac-602;
RX   PubMed=11075930;
RA   Rodriguez-Garcia A., de la Fuente A., Perez-Redondo R., Martin J.F.,
RA   Liras P.;
RT   "Characterization and expression of the arginine biosynthesis gene cluster
RT   of Streptomyces clavuligerus.";
RL   J. Mol. Microbiol. Biotechnol. 2:543-550(2000).
CC   -!- FUNCTION: Regulates arginine biosynthesis genes.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis [regulation].
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ArgR family. {ECO:0000305}.
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DR   EMBL; Z49111; CAB82483.1; -; Genomic_DNA.
DR   PIR; PC4127; PC4127.
DR   AlphaFoldDB; P95721; -.
DR   SMR; P95721; -.
DR   STRING; 443255.SCLAV_0797; -.
DR   eggNOG; COG1438; Bacteria.
DR   UniPathway; UPA00068; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0034618; F:arginine binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0051259; P:protein complex oligomerization; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00173; Arg_repressor; 1.
DR   InterPro; IPR001669; Arg_repress.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR036251; Arg_repress_C_sf.
DR   InterPro; IPR020900; Arg_repress_DNA-bd.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34471; PTHR34471; 1.
DR   Pfam; PF01316; Arg_repressor; 1.
DR   Pfam; PF02863; Arg_repressor_C; 1.
DR   PRINTS; PR01467; ARGREPRESSOR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF55252; SSF55252; 1.
DR   TIGRFAMs; TIGR01529; argR_whole; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; DNA-binding;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..178
FT                   /note="Arginine repressor"
FT                   /id="PRO_0000205123"
SQ   SEQUENCE   178 AA;  18908 MW;  864CA16B3D0F187D CRC64;
     MTEAHATDAG GPAVPQTRMA RHRRIVDILN RQPVRSQSQL AKLLADNGLS VTQATLSRDL
     DELGAVKIRN TMARLIYAVP ARGVPHSAGA LGESAKEERM RRLAGELLIS AEASANLVVL
     RTPPGAAQFL ASAIDQAELH DILGTIAGDD TLMLISRSPT GGQALADHLL RLAQNDRA