MEAK7_DANRE
ID MEAK7_DANRE Reviewed; 450 AA.
AC Q1LWV7; A0JMH4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=MTOR-associated protein MEAK7 {ECO:0000305};
DE Short=MEAK7 {ECO:0000305};
DE AltName: Full=TBC/LysM-associated domain-containing protein 1;
DE AltName: Full=TLD domain-containing protein 1;
GN Name=meak7; Synonyms=KIAA1609, tldc1;
GN ORFNames=si:ch211-260p9.6, zgc:153621;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Activates an alternative mTOR signaling to regulate cell
CC proliferation and migration. {ECO:0000250|UniProtKB:Q6P9B6}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q6P9B6}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q6P9B6}. Lysosome
CC {ECO:0000250|UniProtKB:Q6P9B6}.
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DR EMBL; BX511124; CAK04840.1; -; Genomic_DNA.
DR EMBL; BC125880; AAI25881.1; -; mRNA.
DR RefSeq; NP_001038430.2; NM_001044965.2.
DR RefSeq; XP_017207426.1; XM_017351937.1.
DR AlphaFoldDB; Q1LWV7; -.
DR SMR; Q1LWV7; -.
DR STRING; 7955.ENSDARP00000085993; -.
DR PaxDb; Q1LWV7; -.
DR Ensembl; ENSDART00000091560; ENSDARP00000085993; ENSDARG00000062951.
DR Ensembl; ENSDART00000185684; ENSDARP00000152218; ENSDARG00000068763.
DR GeneID; 561678; -.
DR KEGG; dre:561678; -.
DR CTD; 57707; -.
DR ZFIN; ZDB-GENE-050419-140; meak7.
DR eggNOG; KOG2557; Eukaryota.
DR GeneTree; ENSGT00940000157517; -.
DR GeneTree; ENSGT00940000158087; -.
DR HOGENOM; CLU_036763_2_0_1; -.
DR InParanoid; Q1LWV7; -.
DR OMA; VIEDWVF; -.
DR OrthoDB; 585082at2759; -.
DR PhylomeDB; Q1LWV7; -.
DR TreeFam; TF316541; -.
DR PRO; PR:Q1LWV7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000062951; Expressed in testis and 20 other tissues.
DR ExpressionAtlas; Q1LWV7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0150032; P:positive regulation of protein localization to lysosome; ISS:UniProtKB.
DR GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0043200; P:response to amino acid; ISS:UniProtKB.
DR GO; GO:0032868; P:response to insulin; ISS:UniProtKB.
DR GO; GO:0031667; P:response to nutrient levels; ISS:UniProtKB.
DR GO; GO:0031929; P:TOR signaling; ISS:UniProtKB.
DR InterPro; IPR006571; TLDc_dom.
DR Pfam; PF07534; TLD; 1.
DR SMART; SM00584; TLDc; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lysosome; Membrane; Reference proteome.
FT CHAIN 1..450
FT /note="MTOR-associated protein MEAK7"
FT /id="PRO_0000313643"
FT DOMAIN 236..404
FT /note="TLDc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT REGION 430..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 153
FT /note="H -> Q (in Ref. 2; AAI25881)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="S -> T (in Ref. 2; AAI25881)"
FT /evidence="ECO:0000305"
FT CONFLICT 294
FT /note="Y -> H (in Ref. 2; AAI25881)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="S -> A (in Ref. 2; AAI25881)"
FT /evidence="ECO:0000305"
FT CONFLICT 448
FT /note="D -> G (in Ref. 2; AAI25881)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 450 AA; 49949 MW; 25AC1E9EA640DF9B CRC64;
MGNGDSVVAQ KRLARFRPDE RPAVEGTFDR LHGARSSASA GKTSKGLSLD MLQLTMGKMA
SESMIKRVFQ GLHSIDPGVP LHPGDGVSRE QLLIFLADVL RGTAEERAPL VLAMAEGAKA
TVTTTEQIRG FMEDLVYAAV QTLAHKGHLR AWHPERMGDG AQGVKLLAEQ LTSELKPSDQ
NSCDIACLED WLFRIPMMAM FLELLIGEGL GVVLPSRPPP TLLPPCQFAP WTDLRCVLSL
PLLMFLSPLL PEGHSAPWRM LFSTKMHGES FTRLLGSCKS RGPTVLLVKD TKGYIFGGFS
SQSWEVKPQF QGDSRCFLFS VFPYMRVFTC TGYNDHYMYL NQGQQTMPNG LGMGGQHGYF
GLWLDYDFGH GHSRARPRCT TYGSPQLSAD EDFKLDTLEV WGVGKLPEEQ EEDEKKKSIL
DADLEVQAMM EMTGKTLHSQ GLREPEEDED
