ID   MEAK7_XENLA             Reviewed;         460 AA.
AC   Q6DDZ9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=MTOR-associated protein MEAK7 {ECO:0000305};
DE            Short=MEAK7 {ECO:0000305};
DE   AltName: Full=TBC/LysM-associated domain-containing protein 1;
DE   AltName: Full=TLD domain-containing protein 1;
GN   Name=meak7; Synonyms=KIAA1609, tldc1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Activates an alternative mTOR signaling to regulate cell
CC       proliferation and migration. {ECO:0000250|UniProtKB:Q6P9B6}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q6P9B6}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q6P9B6}. Lysosome
CC       {ECO:0000250|UniProtKB:Q6P9B6}.
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DR   EMBL; BC077349; AAH77349.1; -; mRNA.
DR   RefSeq; NP_001086719.1; NM_001093250.1.
DR   AlphaFoldDB; Q6DDZ9; -.
DR   SMR; Q6DDZ9; -.
DR   MaxQB; Q6DDZ9; -.
DR   DNASU; 446554; -.
DR   GeneID; 446554; -.
DR   KEGG; xla:446554; -.
DR   CTD; 446554; -.
DR   Xenbase; XB-GENE-5927060; meak7.L.
DR   OMA; VIEDWVF; -.
DR   OrthoDB; 585082at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 446554; Expressed in testis and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0150032; P:positive regulation of protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0043200; P:response to amino acid; ISS:UniProtKB.
DR   GO; GO:0032868; P:response to insulin; ISS:UniProtKB.
DR   GO; GO:0031667; P:response to nutrient levels; ISS:UniProtKB.
DR   GO; GO:0031929; P:TOR signaling; ISS:UniProtKB.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..460
FT                   /note="MTOR-associated protein MEAK7"
FT                   /id="PRO_0000313644"
FT   DOMAIN          246..414
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
SQ   SEQUENCE   460 AA;  52084 MW;  051AD81588E3FF07 CRC64;
     MGNTESGSHQ KGLSRILPEE KAEIEQFFEN MCRMQSGPKK SVGLQYFQDA LRNSLPCSIS
     QRIFDGIQSV RTNSKSSTMS AEISKEQFLV FYVDLLRGTA EEKSQVICDM ISCNNSEHMK
     GHQVQKFLED IIAAVIYVLK QQSLLKGWNL ENMRDCTLGT QGLAMQLLSQ LQSIDGQKFE
     RQELLDSPCS KSCIEDWLYK IPMISLFVRV MLTVGLSILK HHTEHQKDMK TLLPKCTGMK
     NTSFVSLLDL PAVMHLNYYL PYEVQHKWRL LFSSQIHGES FSQLCGHILD QGPCLLIVKD
     SDGFVFGGFA SQSWKVKPQF QGDSRCFLFS ISPRLDVYTY TGYNDHYMYL NRAQQSLPNG
     LGMGGQHEYF GFWIDSNFGI GHSKAKPSCT TYNSPQLSAK EEFSIHTVEV WAVGDVPEHL
     LAKNPRSILD SDTEARALLE MAGQTRQSDG LREVTEEDES