MEC10_CAEBR
ID MEC10_CAEBR Reviewed; 724 AA.
AC Q60NC0; A8Y2V5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Degenerin mec-10;
DE AltName: Full=Mechanosensory abnormality protein 10;
GN Name=mec-10 {ECO:0000250|UniProtKB:P34886}; ORFNames=CBG22775;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Amiloride-sensitive sodium channel subunit required for
CC mechanosensory transduction (touch sensitivity). Negatively regulates
CC the turning step of male mating behavior.
CC {ECO:0000250|UniProtKB:P34886}.
CC -!- SUBUNIT: The channel is probably composed of at least the mec-2, mec-4,
CC mec-6 and mec-10 subunits. {ECO:0000250|UniProtKB:P34886}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P34886};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P34886}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000305}.
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DR EMBL; HE601156; CAP39289.1; -; Genomic_DNA.
DR RefSeq; XP_002645519.1; XM_002645473.1.
DR AlphaFoldDB; Q60NC0; -.
DR STRING; 6238.CBG22775; -.
DR EnsemblMetazoa; CBG22775.1; CBG22775.1; WBGene00041260.
DR GeneID; 8587518; -.
DR KEGG; cbr:CBG_22775; -.
DR CTD; 8587518; -.
DR WormBase; CBG22775; CBP24993; WBGene00041260; Cbr-mec-10.
DR eggNOG; KOG4294; Eukaryota.
DR HOGENOM; CLU_017673_0_0_1; -.
DR InParanoid; Q60NC0; -.
DR OMA; MSQAKHN; -.
DR OrthoDB; 686369at2759; -.
DR Proteomes; UP000008549; Chromosome X.
DR GO; GO:0044298; C:cell body membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0050976; P:detection of mechanical stimulus involved in sensory perception of touch; IEA:EnsemblMetazoa.
DR GO; GO:0007638; P:mechanosensory behavior; IEA:EnsemblMetazoa.
DR GO; GO:1905789; P:positive regulation of detection of mechanical stimulus involved in sensory perception of touch; IEA:EnsemblMetazoa.
DR GO; GO:1905792; P:positive regulation of mechanosensory behavior; IEA:EnsemblMetazoa.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004726; Deg-1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690; PTHR11690; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR TIGRFAMs; TIGR00867; deg-1; 1.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Reference proteome; Sensory transduction; Sodium; Sodium channel;
KW Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..724
FT /note="Degenerin mec-10"
FT /id="PRO_0000294930"
FT TOPO_DOM 1..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..684
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 685..705
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 706..724
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 370
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 463
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 605
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 624
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 724 AA; 82166 MW; 19B7F9142076C457 CRC64;
MNRGPPNPRM FKFQPNPKVK NRFQDEADLR SLRSFKTDFS NYLASDTNFL NVAEIMTSYA
YGESNNANEK EIQCDLLTEN GGIEIDPTRL SYRERIRWHL QQFCYKTSSH GIPMLGQAPN
SLYRAVWVFL LLICAIQFIN QAVAVIQKYQ KMDKITDIQL KFDTAPFPAI TLCNLNPYKD
SVIRSHDSIS KILGVFKSVM KKAGDSSAEA SDDGVEYDMD GITIQAKRRK RGAGEKGTFE
PANSACECDE EDGSNECEEK STEKPSSDND MCICAFDRQT NDAWPCHRRE QWTNTTCQAC
DEHYLCSKKA KKGTKRSEIK KEPCICESKG LFCIKHEHAA LVLNLWEYFG DTEEFSDIST
EEREALGFGN MTDEVAIVTK AKENIIFAMS ASEEQRILMS QAKHNLIHKC SFNGKPCDID
KDFELVADPT FGNCFVFNHD REIFKSSVRA GPQYGLRVML FVNASDYLPT SEAVGIRLTI
HDKDDFPFPD TFGYSAPTGY ISSFGMRMKK MSRLPAPYGD CVEDGTTSNY IYKGYAYSTE
GCYRTCFQEL IIDRCGCSDP RFPSIGGVQP CQVFNKNHRE CLEKHTHQIG EIHGSFKCRC
QQPCNQTIYT TSYSEAIWPS QALNISLGHC EKEAEECNEE YKENAAMLEV FYEALNFEVL
AESEAYGIVK MMADFGGHLG LWSGVSVMTC CEFVCLVLEL LYMAVTHHIT QERIRRRENA
ANEF
