ID   MEC3_ASHGO              Reviewed;         386 AA.
AC   Q74ZB0;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=DNA damage checkpoint control protein MEC3;
GN   Name=MEC3; OrderedLocusNames=AGR289C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 265; 269 AND 281-283.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the checkpoint clamp complex involved in the
CC       surveillance mechanism that allows the DNA repair pathways to act to
CC       restore the integrity of the DNA prior to DNA synthesis or separation
CC       of the replicated chromosomes. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the checkpoint clamp complex composed of DDC1,
CC       MEC3 and RAD17. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MEC3 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54779.2; -; Genomic_DNA.
DR   RefSeq; NP_986955.2; NM_212017.2.
DR   AlphaFoldDB; Q74ZB0; -.
DR   STRING; 33169.AAS54779; -.
DR   EnsemblFungi; AAS54779; AAS54779; AGOS_AGR289C.
DR   GeneID; 4623257; -.
DR   KEGG; ago:AGOS_AGR289C; -.
DR   eggNOG; ENOG502RA7D; Eukaryota.
DR   HOGENOM; CLU_597417_0_0_1; -.
DR   InParanoid; Q74ZB0; -.
DR   OMA; EPQVWCK; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0030896; C:checkpoint clamp complex; IBA:GO_Central.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR   GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0044778; P:meiotic DNA integrity checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR   GO; GO:0031509; P:subtelomeric heterochromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblFungi.
DR   InterPro; IPR007150; Hus1/Mec3.
DR   Pfam; PF04005; Hus1; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..386
FT                   /note="DNA damage checkpoint control protein MEC3"
FT                   /id="PRO_0000239639"
SQ   SEQUENCE   386 AA;  43488 MW;  1C9DF3AF45DDC717 CRC64;
     MKLKLVIDSD SDDYRLFKTT ISTVAQLRKT AVLRFTTDRL IVVSTPKTAA SGAILSGDQG
     QLWCTIPRDI FTLYNVASIR EQNAIAMECQ CDSLVNVLRR YERCNHGPLT IKLQSTPEWN
     QVHTGIQQGE ENKPMGNPIC ALSCAFTEHL GYEDSGKEVS HVFKVGVRLL YKSQDARIVE
     PMVNYTKLLM FQLPPVNGEY GSKFTSFVKR LDRYATLNHL MIYGDRNSDR SDEGRLRLLV
     QELDWKLDVQ WRGPLEMIVQ DDQPSAVPAS EPGLVGNVRH LNAGTSMQIE DSEMDIEATD
     IGNVSTSRPS TSVSPQEQTS QVFIKAKDWK VCSKLYDSFE EVVLAISHDE SCVLHCSLDR
     GTVDEHSTKS KERGQIIYYM ARSKPL